Strengths and limitations
To our knowledge, this is the most comprehensive analysis to date of the complement system in patients with PCOS, benefiting from careful anthropometric and metabolic characterisation in addition to measurements in the postprandial as well as the fasting state. Nevertheless, whilst we intentionally sought to compare postprandial complement activation kinetics in a carefully matched population of PCOS subjects and controls, our study was limited by the absence of an additional group of insulin-resistant women with PCOS. We were also limited to a 4-hour study window after the fat challenge.