Conclusions
We demonstrate evidence of complement activation and dysregulation in
women with PCOS which is exacerbated in the presence of obesity and
insulin resistance. We show that this extends to the terminal pathway
and is evident in the postprandial as well as the fasting state. These
disturbances have implications for lipid clearance, inflammation and
insulin sensitivity, and suggest that interventions aimed at regulating
complement activation in PCOS may be helpful in reducing cardiometabolic
risk.