Associations of fasting complement concentrations and
metabolic parameters
The associations between circulating complement levels and a range of
anthropometric and metabolic risk measures are shown in table S2. Across
the whole cohort (PCOS and controls), triglycerides, and to a lesser
extent LDL cholesterol, correlated strongly with early complement
pathway components and activation products but weakly with terminal
components and activation products (C5, C5a(desArg) and TCC). Both early
and late complement pathway components were significantly associated
with both visceral and subcutaneous fat area. HOMA-IR was most strongly
associated with C3, factor H and properdin.