Discussion:
Main FindingsIn this retrospective analysis, we have the following findings. Firstly, late detected abnormal ultrasound finding(s) becomes the most common indication of late amniocentesis. Secondly, compared to cordocentesis, complication rate of late amniocentesis is also competitive, while 88.7% of complications took place in fetuses with abnormal ultrasound findings. Thirdly, compared to traditional karyotyping, both CMA and ES achieve better diagnostic yield. Lastly, 86.4% of women who received pathogenic genetic results terminated the pregnancies, and 24% of women with normal genetic results still terminate the pregnancies owing to the severe ultrasound findings.