Figure 4
The spread of artemisinin resistant P. falciparum parasite lineages across the Greater Mekong subregion (GMS). A single longpfKelch C580Y haplotype (from -50 to +31ยท5kb either side of the Pfkelch gene), which emerged in Western Cambodia in 2008 (Pf Pailin), has spread across the Eastern GMS. In Myanmar C580Y parasites of a different lineage have spread widely and a singlepfKelch F446I haplotype which probably originated in the North of Myanmar has spread widely across the country; modified from Imwong et al (42) with permission.