What this Study Adds
- This article represents an in-depth systematic review and analysis of
the best available evidence linking long-term PPI use to mortality.
- We have highlighted the importance of using a modern standard of
pharmacovigilance research framework for evaluating the serious
adverse events associated with medications.
- Pooled results from 3 observational studies found that long-term PPI
exposure was associated with an increased risk of all-cause mortality.
The greater the PPI exposure, the stronger the association.
- A 10-year observational study of 214,467 people found that PPI
exposure was associated with an increased risk of all-cause mortality.
- The COMPASS, RCT did not find increased mortality after 3-year PPI
exposure in 17, 598 people.
- The RCT findings because of its smaller sample size and shorter
duration are not inconsistent with findings from the observational
studies.