Systematic review and meta-analysis of 3 observational
studies 17
Median follow up 1 year
|
PPI: 765/4,775 (16%)
Non-PPI users: 1,794/17,652 (10%)
|
OR 1.68
(1.53–1.84)
|
US Veterans Affairs
longitudinal cohort study 18
new users of PPI vs. H2RA
Median follow up 10 years
|
PPI: 59,771/157,625 (37.9%)
H2RA: 20,287/56,842 (35.7%)
|
HR 1.17
(1.10-1.24)
45.20 excess deaths/1,000
(28.20–61.40)
|
COMPASS RCT 19
Pantoprazole 40mg/d vs. placebo
Median follow up 3 years
|
PPI: 630/8791 (7.2%)
Placebo: 614/8807 (7.0%)
|
HR 1.03
(0.92–1.15)
|