Searching strategy
Recently in our 2016 systematic review, mortality outcome was not reported in RCTs that directly compared different PPIs4,5. An updated search was performed by information specialist from January 2014-the date of our last comprehensive search and PPI class review to January 2020 in the following databases: PubMed, MEDLINE, EMBASE (through Ovid), the Cochrane Central Register of Controlled Trials (CENTRAL), and the Cochrane Database of Systematic Reviews. The combination of the following medical subheadings (MeSH) and key words was used for database searching: proton pump inhibitors or PPI and adverse events or esomeprazole or pantoprazole or omeprazole or rabeprazole or lansoprazole and any indications. Alternative spellings and abbreviations of the above key words were also considered with no limitation on the language or the publishing date.