Searching strategy
Recently in our 2016 systematic review, mortality outcome was not
reported in RCTs that directly compared different PPIs4,5. An updated search was performed by information
specialist from January 2014-the date of our last comprehensive search
and PPI class review to January 2020 in the following databases: PubMed,
MEDLINE, EMBASE (through Ovid), the Cochrane Central Register of
Controlled Trials (CENTRAL), and the Cochrane Database of Systematic
Reviews. The combination of the following medical subheadings (MeSH) and
key words was used for database searching: proton pump inhibitors or PPI
and adverse events or esomeprazole or pantoprazole or omeprazole or
rabeprazole or lansoprazole and any indications. Alternative spellings
and abbreviations of the above key words were also considered with no
limitation on the language or the publishing date.