Umifenovir
Umifenovir, an indole-based, hydrophobic, dual-acting active antiviral /
host-targeting agent, used for influenza and other respiratory
infections treatment and prophylaxis. The ability of Umifenovir to exert
antiviral effects across several mechanisms has led to extensive work
into its use for a number of enveloped and non-enveloped RNA and DNA
viruses, including Flavivirus, Zika virus, Foot-and-mouth disease, Lassa
virus, Ebola virus, Herpes simplex, Hepatitis B and C virus, Chikungunya
virus, Reovirus, Hantaan virus and Coxsackie virus B5 [38].
Umifenovir is currently being investigated in conjunction with currently
available and investigational HIV therapies as a potential treatment and
prophylactic agent for COVID-19 caused by SARS-CoV2 infections [37].