Key points
●T he purpose of this study was to explore the demographics, treatment outcomes, and prognostic factors of salvage endoscopic nasopharyngectomy in recurrent nasopharyngeal carcinoma (NPC).
●T he overall 1-, 3- and 5-year survival rates were 82.2%, 59.5%, and 43.6%.
●I n subjects over 50 years of age, diabetes, low BMI (<20 kg/m2), increased NLR (≥6), advanced T stage (rT3 and rT4), lymph node metastasis, and tumor necrosis are the independent prognostic factor for overall survival.
●T umor necrosis was a better predictor for disease recurrence (area under the receiver operating curve [AUROC; 0.347; p <0.001) than other clinical features.
Keywords : Nasopharyngeal carcinoma, Recurrent, Endoscopic, Nasopharyngectomy, Prognostic factors, Tumor necrosis