|
Metformin |
Basal |
p-value |
12M |
p-value |
24M |
p-value |
36M |
p-value |
Creatinine
(mean ± SD)
|
No
|
0.92±0,24
|
0.257
|
0.96±0.34
|
0.263
|
0.91±0.30
|
0.320
|
0.91±0.29
|
0.916
|
|
Yes |
0.83±0.29 |
|
0.86±0.29 |
|
0.83±0.25 |
|
0.90±0.37 |
|
Glomerular filtrate
(mean ± SD)
|
No
|
77.27±23.43
|
0.149
|
77.42±28.57
|
0.397
|
80.94±28.19
|
0.491
|
80.33±30.34
|
0.781
|
|
Yes |
88.84±27.81 |
|
83.68±25.17 |
|
85.79±23.92 |
|
82.28±29.59 |
|
|
Sulfonylureas |
|
|
|
|
|
|
|
|
Creatinine
(mean ± SD)
|
No
|
0.84±0.26
|
0.700
|
0.89±0.31
|
0.454
|
0.85±0.28
|
0.607
|
0.91±0.36
|
0.892
|
|
Yes |
0.86±0.33 |
|
0.84±0.25 |
|
0.82±0.20 |
|
0.89±0.37 |
|
Glomerular filtrate
(mean ± SD)
|
No
|
88.32±27.59
|
0.450
|
82.36±25.80
|
0.901
|
85.51±25.21
|
0.729
|
82.71±30.08
|
0.822
|
|
Yes |
83.24±26.95 |
|
83.16±26.18 |
|
83.41±23.35 |
|
81.08±28.82 |
|
|
DPP-4i |
|
|
|
|
|
|
|
|
Creatinine
(mean ± SD)
|
No
|
0.83±0.26
|
0.554
|
0.86±0.25
|
0.534
|
0.86±0.28
|
0.549
|
0.92±0.36
|
0.631
|
|
Yes |
0.87±0.31 |
|
0.90±0.36 |
|
0.82±0.22 |
|
0.88±0.36 |
|
Glomerular filtrate
(mean ± SD)
|
No
|
87.49±26.05
|
0.811
|
82.82±24.22
|
0.904
|
84.40±25.87
|
0.782
|
80.67±29.84
|
0.506
|
|
Yes |
86.01±29.94 |
|
82.11±28.70 |
|
85.94±24.60 |
|
85.12±29.40 |
|
|
SGLT2i |
|
|
|
|
|
|
|
|
Creatinine
(mean ± SD)
|
No
|
0.85±0.29
|
0.747
|
0.90±0.32
|
0.321
|
0.84±0.27
|
0.800
|
0.89±0.34
|
0.724
|
|
Yes |
0.83±0.27 |
|
0.83±0.25 |
|
0.85±0.23 |
|
0.92±0.39 |
|
Glomerular filtrate
(mean ± SD)
|
No
|
87.02±29.96
|
0.980
|
80.51±24.20
|
0.329
|
87.05±25.34
|
0.292
|
83.31±29.60
|
0.668
|
|
Yes |
86.86±28.49 |
|
86.27±28.35 |
|
81.20±23.26 |
|
80.44±29.95 |
|
|
Insulin |
|
|
|
|
|
|
|
|
Creatinine
(mean ± SD)
|
No
|
0.79±0.27
|
0.101
|
0.78±0.25
|
0.013
|
0.80±0.26
|
0.167
|
0.82±0.36
|
0.086
|
|
Yes |
0.89±0.28 |
|
0.95±0.31 |
|
0.88±0.25 |
|
0.96±0.35 |
|
Glomerular filtrate
(mean ± SD)
|
No
|
92.72±25.19
|
0.098
|
91.28±24.01
|
0.008
|
89.41±22.52
|
0.155
|
89.36±28.14
|
0.066
|
|
Yes |
82.81±28.33 |
|
76.34±25.34 |
|
81.73±25.74 |
|
77.42±29.84 |
|