Analytical variable Drug intake Time (moths) Time (moths) Time (moths) Time (moths) Time (moths) Time (moths) Time (moths) Time (moths)
Metformin Basal p-value 12M p-value 24M p-value 36M p-value
Creatinine (mean ± SD)
No
0.92±0,24
0.257
0.96±0.34
0.263
0.91±0.30
0.320
0.91±0.29
0.916
Yes 0.83±0.29 0.86±0.29 0.83±0.25 0.90±0.37
Glomerular filtrate (mean ± SD)
No
77.27±23.43
0.149
77.42±28.57
0.397
80.94±28.19
0.491
80.33±30.34
0.781
Yes 88.84±27.81 83.68±25.17 85.79±23.92 82.28±29.59
Sulfonylureas
Creatinine (mean ± SD)
No
0.84±0.26
0.700
0.89±0.31
0.454
0.85±0.28
0.607
0.91±0.36
0.892
Yes 0.86±0.33 0.84±0.25 0.82±0.20 0.89±0.37
Glomerular filtrate (mean ± SD)
No
88.32±27.59
0.450
82.36±25.80
0.901
85.51±25.21
0.729
82.71±30.08
0.822
Yes 83.24±26.95 83.16±26.18 83.41±23.35 81.08±28.82
DPP-4i
Creatinine (mean ± SD)
No
0.83±0.26
0.554
0.86±0.25
0.534
0.86±0.28
0.549
0.92±0.36
0.631
Yes 0.87±0.31 0.90±0.36 0.82±0.22 0.88±0.36
Glomerular filtrate (mean ± SD)
No
87.49±26.05
0.811
82.82±24.22
0.904
84.40±25.87
0.782
80.67±29.84
0.506
Yes 86.01±29.94 82.11±28.70 85.94±24.60 85.12±29.40
SGLT2i
Creatinine (mean ± SD)
No
0.85±0.29
0.747
0.90±0.32
0.321
0.84±0.27
0.800
0.89±0.34
0.724
Yes 0.83±0.27 0.83±0.25 0.85±0.23 0.92±0.39
Glomerular filtrate (mean ± SD)
No
87.02±29.96
0.980
80.51±24.20
0.329
87.05±25.34
0.292
83.31±29.60
0.668
Yes 86.86±28.49 86.27±28.35 81.20±23.26 80.44±29.95
Insulin
Creatinine (mean ± SD)
No
0.79±0.27
0.101
0.78±0.25
0.013
0.80±0.26
0.167
0.82±0.36
0.086
Yes 0.89±0.28 0.95±0.31 0.88±0.25 0.96±0.35
Glomerular filtrate (mean ± SD)
No
92.72±25.19
0.098
91.28±24.01
0.008
89.41±22.52
0.155
89.36±28.14
0.066
Yes 82.81±28.33 76.34±25.34 81.73±25.74 77.42±29.84