Statistical Methods
Demographic information and absolute imaging diameters at the level of
the sinuses of Valsalva (SoV) and ascending aorta (AAo) were obtained.
All echocardiogram Z-scores were either obtained directly from the
reports or calculated [12, 13]. For advanced imaging where
bi-orthogonal measurements were obtained, the largest diameter was used
in the analysis. Data was also analyzed by dividing the patients into
two groups: birth -16 years of age and 17-30 years of age (Tables 5-6).
Genetics diagnoses were obtained from laboratory reports or
documentation from the cardiac geneticist or primary cardiologist (Table
2). Echocardiographic aortic dimensions were analyzed using median and
interquartile ranges. Pearson correlation was used to compare
echocardiography and advanced imaging aortic dimensions and p-values
calculated using R (R Project for Statistical
Computing, version 3.5.1). Bland-Altman (B-A) analysis plots [14]
were created to compare differences of measurements between echo and
advanced imaging at the SoV and AAo using R.