Outcome
Expectant management (N=639) Embryo reduction (N=622)
Unadjusted odds ratio (95% CI)
p-value c
Adjusted odds ratio (95% CI)
p-value c
Survivalc
Survival during 2 hours after birth* 612 (95.8) 552 (88.7) 2.87 (1.54-5.37) 0.001 3.13 (1.57-6.22) 0.001
Survival to discharge* 607 (95.0) 545 (87.6) 2.68 (1.49-4.82) 0.001 2.82 (1.46-5.44) 0.002
Neonatal characteristicsa (N=632) (N=564)
Gender (male) * 324/616 (52.6) 291/560 (53.5)
Birth weight (gram) † 1851 ± 472 2307 ± 545
Apgar score at 5min <7* 52/623 (8.3) 33/563 (5.9) 1.47 (0.84-2.57) 0.176 1.70 (0.96-3.01) 0.067
NIUC admission* 313/621 (50.4) 201/553 (36.3) 1.83 (1.32-2.53) <0.001 1.58 (1.12-2.24) 0.010
Morbidity during hospitalizationb (N=593) (N=526)
Neonatal sepsis* 10 (1.7) 27 (5.1) 0.32 (0.13-0.82) 0.017 0.36 (0.16-0.76) 0.009
Intracerebral hemorrhage* 11 (1.9) 15 (2.9) 0.61 (0.21-1.77) 0.364 0.79 (0.29-2.16) 0.645
Retinopathy of prematurity* 26 (4.4) 35 (6.7) 0.67 (0.33-1.37) 0.272 0.66 (0.30-1.41) 0.282
Patent ductus arteriosus* 65 (11.0) 23 (4.4) 2.57 (1.40-4.70) 0.002 2.63 (1.39-5.00) 0.003
Pulmonary hypertension* 8 (1.3) 1 (0.2) 6.08 (0.72-51.62) 0.098 6.91 (1.51-65.49) 0.019
Respiratory distress syndrome* 86 (14.5) 85 (16.2) 0.88 (0.57-1.36) 0.566 0.92 (0.56-1.51) 0.741
Bronchopulmonary dysplasia* 26 (4.4) 4 (0.8) 6.56 (1.69-25.51) 0.007 4.23 (1.59-13.86) 0.006
Necrotizing enterocolitis* 5 (0.8) 3 (0.6) 1.42 (0.31-6.61) 0.654 1.65 (0.41-7.47) 0.441
Composite morbidity during hospitalization* 113 (19.1) 105 (20.0) 0.94 (0.64-1.39) 0.763 0.96 (0.62-1.49) 0.844
Morbidity at present (N=451) (N=507)
Developmental delay* 9 (2.0) 20 (3.9) 0.50 (0.20-1.27) 0.147 0.47 (0.20-1.11) 0.087
Cerebral palsy* 2 (0.4) 10 (2.0) 0.22 (0.05-1.03) 0.055 0.41 (0.08-1.45) 0.179