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The association between serum levels of growth differentiation factor-15 and rheumatoid arthritis activity
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  • Kamal Esalatmanesh,
  • Hamidreza Fayyazi,
  • Roozbeh Esalatmanesh,
  • Alireza Khabbazi
Kamal Esalatmanesh
Autoimmune Diseases Research Center, Kashan University of Medical Sciences
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Hamidreza Fayyazi
Autoimmune Diseases Research Center, Kashan University of Medical Sciences
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Roozbeh Esalatmanesh
Autoimmune Diseases Research Center, Kashan University of Medical Sciences
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Alireza Khabbazi
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Peer review status:ACCEPTED

14 Apr 2020Submitted to International Journal of Clinical Practice
21 Apr 2020Submission Checks Completed
21 Apr 2020Assigned to Editor
25 Apr 2020Reviewer(s) Assigned
30 Apr 2020Review(s) Completed, Editorial Evaluation Pending
20 May 20201st Revision Received
21 May 2020Reviewer(s) Assigned
21 May 2020Submission Checks Completed
21 May 2020Assigned to Editor
22 May 2020Review(s) Completed, Editorial Evaluation Pending
26 May 2020Editorial Decision: Accept

Abstract

Background: Macrophages play a crucial role in the pathogenesis of rheumatoid arthritis (RA). Growth differentiation factor-15 (GDF-15) acts as an autocrine regulator of macrophage activation. Objective: The aim of this study was to assess serum level of GDF-15 as a potential biomarker for detecting RA activity. Method: A total of 100 female RA patients and 55 age matched healthy control females were enrolled. The serum level of GDF-15 was measured using enzyme-linked immunosorbent assay by an eBioscience kit. Results: Serum levels of GDF-15 in RA patients with high, moderate, low and no disease activity were 989.0±161.9, 505.6±220.5, 349.2±155.9 and 349.0±144.0 pg/ml, respectively. GDF-15 with a cut-off value higher than 705 pg/ml was indicative of high RA activity with sensitivity of 96% and specificity of 92%. Conclusion: GDF-15 serum levels may be used as a biomarker to predict high RA disease activity.