Introduction
Lymphadenopathy (LAD) can present features including connective tissue
diseases, malignancy, and infections. A histopathological evaluation for
a definitive diagnosis should be conducted in specific clinical
scenarios. Systemic lupus erythematosus (SLE) is an autoimmune and
chronic disease involving multi-organs (1, 2).
In approximately 60% of SLE cases, generalized or localized LAD are
prevalent findings. Numerous case reports have shown that the SLE’s
initial clinical manifestation might be generalized LAD and is
considered as an SLE non-specific feature (3, 4).
Castleman disease (CD) is a rare lymphoproliferative disorder
characterized by heterogeneous manifestations from diffuse recurrent
episodes of lymphadenopathy with severe systemic symptoms to
asymptomatic LAD. There are some CD case reports accompanying SLE.(5-7).
Hence, this article illustrates a rare CD case presenting LAD in a
patient with SLE.