ACEi/ARB: angiotensin-converting-enzyme inhibitor/angiotensin receptor
blocker; CCI: Charlson comorbidity index; eGFR: estimated glomerular
filtration rate; LVEF: left ventricular ejection fraction.
FIGURE LEGENDS
Figure 1: Study flowchart
Figure 2: Dissimilarity matrix defined by Kendall distance and
multiscale bootstrap resampling. In the matrix square, the color level
is proportional to the similarity value between the observations. If it
is red, the distance between the variables is 0 (high similarity) and if
it is green, the distance is the highest (low similarity). In the
multiscale bootstrap resampling [approximately unbiased probability
(AU) in red; bootstrap probability (BP) in green]. The greater the
value of both, the more significantly representative the grouping of the
variables included.
Panel A: Patients with HFpEF and T2DM. Panel B: Patients with HFpEF and
without T2DM.
BMI: body mass index; COPD: Chronic obstructive pulmonary disease; eGFR:
estimated glomerular filtration ratio by MDRD formula; HB: hemoglobin;
SBP: systolic blood pressure.
Figure 3: Descriptive figure of the clusters (above) and Kaplan Meier
curves (below).
Supplementary figure 1: Dendrograms of patients with and without type 2
diabetes mellitus, with their corresponding clusters.
APPENDIX 1
Membership of RICA registry:
Álvarez Rocha P, Anarte L, Arévalo-Lorido JC, Carrascosa S,
Carretero-Gómez J, Cepeda JM, Díez-Manglano J, Epelde F, Fabra Juana S,
García Escrivá D, García López P, Gómez Huelgas R, González Franco A,
León Acuña A, Llàcer P, López-Castellanos G, Manzano L,
Montero-Pérez-Barquero M, Ormaechea G, Pérez Silvestre J, Quesada Simón
MA, Roca Villanueva B, Ruiz Ortega R, Soler Rangel ML, Suárez Pedreira
I, Trullàs JC.