162/Pharma/SCRI/2017.
2.2Dose calculation (5)
The clinical dose of Urai mathirai in children is 50 mg (HED = 2.5mg/kg body weight). The animal (rat) doses are calculated as per the FDA guidelines and the calculated therapeutic dose (TD) was found to be 10mg/kg of body weight. In this study to determine the dose correlated effects, 5 times TD and 10 times TD i.e. 50 mg/kg & 100 mg/kg of bodyweight were chosen correspondingly.