Author contribution
This study was designed by T.-M. Ou, Y. Rao, and Q. Zhang. Q. Zhang, S. Q. Chen, J. W. Sun., Z. Y. Sun, W. Peng, G. T. Kuang, X. X. Su, X. N. Wang, performed biologic evaluation, animal study and mechanism study ofAST and CAG . Y. Rao, T.-M. Ou provided reagents, materials and analysis tools. Data was analyzed and interpreted by Y. Rao, T.-M. Ou. The manuscript was written by Q. Zhang, Y. Rao. T.-M. Ou, with input from all authors.