KEY RESULTS
CAG showed stronger effects in lowering plasma glucose and
enhancing glucose tolerance than AST in KM mice and ZDF rats.
In the ZDF rats, the potential antidiabetic properties of CAGwere associated with amelioration in hyperglycemia, dyslipidemia,
myocardial and kidney fibrosis. Interestingly, glucose reuptake was
inhibited in the kidneys of mice treated with CAG , while urine
glucose and sodium levels were elevated. The underlying mechanism might
be that CAG reduced the expression of SGLT2 in the kidney and
inhibited glucose transport as well.