EXPERIMENTAL APPROACH
The plasma glucose-decreasing effects of AST and CAGwere monitored in KunMing mice by performing an OGTT test. Furthermore, the effect of CAG on the metabolism of Zuker diabetic fat (ZDF) rats was demonstrated after treatment for 5 weeks, as well as on diabetes-relevant clinical symptoms and glucose absorbance. The underlying molecular mechanism of the therapeutic effects of CAG was explored in both wild-type and sodium/glucose co-transporter 2 (SGLT2)-overexpressed HEK293 cells.