KEY RESULTS
CAG showed stronger effects in lowering plasma glucose and enhancing glucose tolerance than AST in KM mice and ZDF rats. In the ZDF rats, the potential antidiabetic properties of CAGwere associated with amelioration in hyperglycemia, dyslipidemia, myocardial and kidney fibrosis. Interestingly, glucose reuptake was inhibited in the kidneys of mice treated with CAG , while urine glucose and sodium levels were elevated. The underlying mechanism might be that CAG reduced the expression of SGLT2 in the kidney and inhibited glucose transport as well.