Potential targets and plausible drugs of Coronavirus infection caused by
The world is confronting a dire situation due to the recent pandemic of
the novel coronavirus disease (2019-nCoV) with so far mortality cases of
100,000 all over the world. Currently, there are no effective enough
treatment options for this previously unknown virus. The current drugs
in pipline and some plausible drug are overviewed in this paper. The
potential molecular targets of each steps of the 2019-nCoV drug life
cycle is discussed and highlights here. Although different types of
anti-viral targets are applicable for 2019-nCoV drug screenings, the
more promising targets can be considered as protease and RNA polymerase.
Based on the results from antiviral agents repurposing and clinical
studies, the remdesivir could be an encouraging drug in the frontline to
be administrated for 2019-nCoV. Much progress in understanding the
2019-nCoV the molecular details of its life cycle followed by the
identification of therapeutic targets seems to be an efficient approach
in discovering potential drugs.