GETV HNJZ-S1 has obvious pathogenicity in pregnant mice and
neonatal mice the
Five pregnant mice gave the birth of 57 mummified fetuses
(Figure 5A ) and miscarriages (Figure 5B ) between 3 and
6 days after exposure with HNJZ-S1, as well as 11 normal spring.
Meanwhile, 67 normal offspring were
born in five litters from the control group (Figure 5C ). There
were no mummified fetuses or miscarriages found in the control group.
Thus, composition of average litter size was significantly different
between the HNJZ-S1 infection and non-infect groups (Figure
5D ). GETV was confirmed from aborted fetuses and premature offspring by
RT-PCR.
Mice at age of postnatal day 3 were incubated with HNJZ-S1. All the
infected group showed severe hindlimb paralysis and slow growth after
three days exposure, and there were no survivals beyond 10 days after
exposure (Figure 6A ). There was no obvious abnormality in
newborn mice of the control group (Figure 6B ).