3.5. Effect on levels of expression of miRNA-122 in tumor
tissue:
MiRNA-122 expression levels were determined in the tumor tissue of
sacrificed mice. The expression of miRNA-122 was significantly
downregulated in the mice with induced breast cancer (p<0.001)
compared to the normal group. Its expression was significantly
upregulated in all treatment groups. Treatment with
Benzoimidazoquinazoline (10mg/kg) gave almost similar expression levels
as the group treated with cisplatin. The expression of miRNA-122 was
significantly higher in both groups treated with benzimidazotriazine
compared to the cisplatin group (p<0.05). Interestingly, the
expression levels upon treatment with the higher dose of
benzimidazotriazine (10mg/kg) were not significantly different from the
normal group (Fig. 5) .