3.5. Effect on levels of expression of miRNA-122 in tumor tissue:
MiRNA-122 expression levels were determined in the tumor tissue of sacrificed mice. The expression of miRNA-122 was significantly downregulated in the mice with induced breast cancer (p<0.001) compared to the normal group. Its expression was significantly upregulated in all treatment groups. Treatment with Benzoimidazoquinazoline (10mg/kg) gave almost similar expression levels as the group treated with cisplatin. The expression of miRNA-122 was significantly higher in both groups treated with benzimidazotriazine compared to the cisplatin group (p<0.05). Interestingly, the expression levels upon treatment with the higher dose of benzimidazotriazine (10mg/kg) were not significantly different from the normal group (Fig. 5) .