and Tissue Doppler Echocardiography in Patients with Thalassemia Major
Melike SEZGİN EVİM1, Özlem Mehtap BOSTAN2, Aysel AYDIN KADERLİ3, Birol BAYTAN1, Yeşim Özarda4, Adalet MERAL GÜNEŞ1
1Uludag University Medical Faculty, Department of Pediatric Hematology, Bursa, TURKEY
2Uludag University Medical Faculty, Department of Pediatric Cardiology, Bursa, TURKEY
3 Medicana Private Hospital, Department of Cardiology, Bursa, TURKEY
4Uludag University Medical Faculty, Department of Medical Biochemistry, Bursa, TURKEY
Word counts Abstract :247
Text: 2267
References: 26, Tables: 3, Figures:2
Melike SEZGİN EVİM
Assoc.Prof. MD Uludag University Medical Faculty.Dpt.of. Pediatric Hematology
BURSA/TURKEY +90 224 295 06 04 melikevim@yahoo.com
Özlem Mehtap BOSTAN
Prof. MD Uludag University Medical Faculty, Department of Pediatric Cardiology
BURSA/TURKEY +90 224 295 04 22 ombostan@uludag.edu.tr
Aysel AYDIN KADERLİ
Assoc.Prof.MD Medicana Private Hospital, Department of Cardiology
BURSA/TURKEY +90 533464 90 39 ayselkaderli@yahoo.com
Birol BAYTAN
Prof. MD Uludag University Medical Faculty.Dpt.of. Pediatric Hematology
BURSA/TURKEY +90 224 295 06 03baytanbirol@yahoo.com
Yeşim ÖZARDA
Prof. MD Uludag University Medical Faculty, Department of Medical Biochemistry
BURSA/TURKEY +90 224 295 3917 yesim@uludag.edu.tr
Adalet MERAL GÜNEŞ
Prof. MD Uludag University Medical Faculty.Dpt.of. Pediatric Hematology
BURSA/TURKEY +90 224 295 06 01adaletm@uludag.edu.tr
Correspondent Author: Melike SEZGİN EVİMmelikevim@yahoo.com
Key Words: Tissue Doppler, Cardiac Dysfunction, Thalassemia Major
Author Contributions:
Melike SEZGİN EVİM: Design, Data Collections, Drafting Article, Statistics
Özlem Mehtap BOSTAN: Data Analysis, Data Collections, Critical Revision of Article
Aysel AYDIN KADERLİ: Data Analysis, Data Collections, Critical Revision of Article
Birol BAYTAN: Design, Drafting Article, Critical Revision of Article
Yeşim ÖZARDA:Design, Data Collections, Data Analysis, Drafting Article
Adalet MERAL GÜNEŞ: Design, Drafting Article, Critical Revision of Article
Background: Tissue Doppler (TD) measurements give a better information in evaluating the myocardial functions than conventional echocardiography in beta-thalassemia major (β-TM). The aim of this study was to determine cardiac status of thalassemia patients by using both T2*MRI and TD.
Methods: The study group included thalassemia patients (n=33) with normal systolic functions defined by conventional echocardiography. The control group (n=37) consisted of age and sex matched healthy individuals. TD measurements from three different regions of myocardium were obtained in both groups. Ferritin was examined in both groups, T2*MRI was performed only patients with thalassemia.
Results: Systolic and diastolic functions were found normal by conventional echocardiography in thalassemia patients. However, cardiac functions were significantly impaired when evaluated by TD (p<0.05). T2*MRI and TD measurements didn’t differ according to serum ferritin levels (p>0.05). Twenty-one patients (63.6%) had myocardial iron overload. Both isovolumetric acceleration time of left ventricle and myocardial performance index (MPI-septal) were found significantly impaired in these patients (p<0.05). There was negative correlation between MPI-septal and T2*MRI measurements in thalassemia patients (r:-0.343, p=0.050). TD measurements obtained from septum were found similar with the control (p>0.05) but, the same measurements from left and right ventricular walls were significantly impaired in iron unloaded group (p< 0.05).
Conclusion: Iron unloaded patients according to T2*MRI had left and right ventricular dysfunction determined by TD. Therefore, we suggest that combining T2*MRI with TD measurements, for evaluating cardiac status in β-TM, in whose with normal T2*MRI scores, would be better management of cardiac complications.