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CLINICAL SIGNIFICANCE OF TISSUE DOPPLER IMAGING IN CHRONIC CHAGAS DISEASE
  • +7
  • Tomás Cianciulli,
  • María Saccheri,
  • Alonso Papantoniou,
  • Nilda Prado,
  • Adelina Riarte,
  • Ricardo Mendez,
  • Javier Clerici,
  • Martín Beck,
  • Jorge Lax,
  • Juan Gagliardi
Tomás Cianciulli
Hospital del Gobierno de la Ciudad de Buenos Aires "Dr. Cosme Argerich"
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María Saccheri
Hospital "Dr. Cosme Argerich"
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Alonso Papantoniou
Hospital Argerich
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Nilda Prado
Hospital del Gobierno de la Ciudad de Buenos Aires "Dr. Cosme Argerich"
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Adelina Riarte
Instituto Nacional de Parasitologia "Dr. Fatala Chaben"
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Ricardo Mendez
Hospital del Gobierno de la Ciudad de Buenos Aires "Dr. Cosme Argerich"
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Javier Clerici
Hospital del Gobierno de la Ciudad de Buenos Aires "Dr. Cosme Argerich"
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Martín Beck
Hospital del Gobierno de la Ciudad de Buenos Aires "Dr. Cosme Argerich"
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Jorge Lax
Hospital del Gobierno de la Ciudad de Buenos Aires "Dr. Cosme Argerich"
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Juan Gagliardi
Hospital del Gobierno de la Ciudad de Buenos Aires "Dr. Cosme Argerich"
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Peer review status:ACCEPTED

16 Apr 2020Submitted to Echocardiography
25 Apr 2020Submission Checks Completed
25 Apr 2020Assigned to Editor
26 Apr 2020Reviewer(s) Assigned
16 Jun 2020Review(s) Completed, Editorial Evaluation Pending
16 Jun 2020Editorial Decision: Revise Minor
18 Jun 20201st Revision Received
21 Jun 2020Submission Checks Completed
21 Jun 2020Assigned to Editor
21 Jun 2020Reviewer(s) Assigned
22 Jun 2020Review(s) Completed, Editorial Evaluation Pending
22 Jun 2020Editorial Decision: Revise Minor
22 Jun 20202nd Revision Received
22 Jun 2020Assigned to Editor
22 Jun 2020Submission Checks Completed
22 Jun 2020Reviewer(s) Assigned
22 Jun 2020Review(s) Completed, Editorial Evaluation Pending
23 Jun 2020Editorial Decision: Revise Minor
23 Jun 20203rd Revision Received
24 Jun 2020Assigned to Editor
24 Jun 2020Submission Checks Completed
24 Jun 2020Reviewer(s) Assigned
26 Jun 2020Review(s) Completed, Editorial Evaluation Pending
26 Jun 2020Editorial Decision: Revise Minor
27 Jun 20204th Revision Received
27 Jun 2020Submission Checks Completed
27 Jun 2020Assigned to Editor
27 Jun 2020Reviewer(s) Assigned
28 Jun 2020Review(s) Completed, Editorial Evaluation Pending
28 Jun 2020Editorial Decision: Accept

Abstract

Introduction: Chagas disease is one of the main diseases in Latin America and heart involvement is its main characteristics, and the main cause of death. The aim of this study is to evaluate if there is any parameter of Doppler Tissue Imaging (DTI) which can be used as a predictor for later events in chronic Chagas disease. Methods: we analyses DTI variables of 543 patients with chronic Chagas disease for the evaluation of predicting factors of events. Major adverse cardiovascular events (MACE) were considered as stroke, heart failure resistant to treatment, sustained ventricular tachycardia, implantable cardioverter-defibrillator, sudden death, and cardiovascular death. The following findings were also included in total evens: heart failure, bradycardia, ventricular arrhythmia, new conduction system abnormalities and new echocardiographic abnormalities. Multivariate analysis with logistic regression was used in order to assess the Doppler and DTI parameters predicting events. Variables with a p-value ≤ 0.10 in the univariate analysis were included in the multivariate analysis. Results: In patients with chronic Chagas disease, the analysis of DTI parameters showed that S’ wave and E’ wave of the lateral wall of the left ventricle were significant predictors of MACE (OR: 0.83; 95% CI: 0.71-0.96; p value: 0.015 and OR: 0.80; 95% CI: 0.66-0.98; p value: 0.031, respectively). Conclusions: This study found that patients with chronic Chagas disease who had events showed significantly lower parameters in the DTI. What is more, this study showed that even lower DTI parameters are significant predictors of events.