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Using Ozone Therapy as an Option for Treatment of COVID-19 Patients: A scoping review
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  • sakineh hajebrahimi,
  • Negar Taleschian-tabrizi,
  • sepideh Karkon-shayan,
  • Fariba pashazadeh,
  • sarvin radvar,
  • ali motamed-sanaye,
  • Amirreza Tavassoli
sakineh hajebrahimi
Tabriz University of Medical Sciences
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Negar Taleschian-tabrizi
Tabriz University of Medical Sciences
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sepideh Karkon-shayan
Gonabad University of Medical Sciences
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Fariba pashazadeh
Tabriz University of Medical Sciences
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sarvin radvar
Tabriz University of Medical Sciences
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ali motamed-sanaye
Gonabad University of Medical Sciences
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Amirreza Tavassoli
Tabriz University
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Abstract

Background: Recently, there has been a global demand toward finding new treatments to control the new pandemic of coronavirus (COVID-19). The aim of this systematic review was to study the effects of ozone therapy on COVID-19 patients, as well as reviewing the available supporting evidence. Methods: Electronic databases including MEDLINE (via PubMed), EMBASE, Cochrane Library (CENTRAL), and TRIP, as well as clinical trial registries and preprint sources were searched for published evidence-based articles. In addition, a hand searching was conducted regarding the attained articles published until 6 April 2020 using MeSH and free text keywords with no language limitation. Articles were screened, categorized and extracted for the relative data, which are reported in a descriptive manner. Results: Among 234 articles, 9 were selected to be reviewed for the inclusion criteria. No previously published original articles were found on the efficacy of ozone therapy on COVID-19. Five review studies on the potential role of systemic ozone therapy were found, in which it was concluded that ozone therapy is effective in controlling COVID-19 due to its antiviral, oxygenating, anti-inflammatory, oxidation balancing and immunomodulation effects. Three ongoing clinical trials were registered in China. Moreover, a preliminary report of an ongoing study in Italy on 46 patients (11 intubated and 35 non-intubated) indicated that 39 patients (84%) showed an improvement for the symptoms of the disease. Conclusion: Despite the promising hypothetical background, opinions of the expert arguing about the benefits of this method, and a preliminary report indicating the effectiveness of ozone therapy as a novel treatment option for COVID-19, there is still not enough evidence to prove it.