In the present study, a total of 76 patients were
screened. Ten patients were excluded because four patients had secondary
hypertension, three patients did not wish to participate in the study
and three patients were not able to comprehend the tests for memory and
psychomotor assessment. In the Telmisartan group 33 patients were
enrolled. Out of 33 participants one participant discontinued the study
due to personal reasons and two discontinued the treatment. In the
Cilnidipine group 33 patients were enrolled. Out of 33 participants two
discontinued the treatment and one patient was lost to follow up. So in
final analysis 60 participants were evaluated, 30 in each group
(Figure - 1). No patient was disqualified due to non-response to study
drugs at one month. Thirty-five were males and 25 were females. The mean
age of patients was 45.13 ± 5.2 years. Demographic data is given in
table - 1.Primary Outcomes: 1. Effects on Memory:Remote Memory and Recent memory scores: There was a significant
improvement in Telmisartan group (p < 0.05) in remote and
recent memory scores at the end of study compared to baseline. The mean
percentage increase of remote memory score was 5.53 % and in recent
memory was 3.66%. No significant improvement was observed in
Cilnidipine group. The mean percentage increase of remote memory score
was 5.21 % and was 2.82 % after three months. The actual values were
given in Table - 2. There was no significant improvement in remote and
recent memory scores between Telmisartan and Cilnidipine groups.Mental balance scores: There was no significant improvement in
mental balance scores at the end of the study in both study groups as
well as between the groups (Table - 2).Attention and concentration scores: Both the study groups
showed a significant (p < 0.05) improvement in attention and
concentration score after three months compared to baseline. The mean
percentage increase was 4.95 % in Telmisartan group and 4.86% in
Cilnidipine group. No significant improvement in was observed between
Telmisartan and Cilnidipine group at three months (Table - 2).Visual retention test: There was an improvement in visual
retention score in Cilnidipine group (0.86 %) after three months, which
was statistically not significant. In Telmisartan group, a decrease of
visual retention score (1.79%) was observed at the end of the study,
which was also not statistically significant (Table - 2). Cilnidipine
significantly (P < 0.05) improved Visual retention score when
compared to Telmisartan at the end of study
(Figure - 2).
No significant improvement was observed in delayed recall,
Immediate recall, verbal retention of similar pairs, verbal retention of
dissimilar pairs and Visual Recognition scores at the end of the study
in both the study groups as well as between the groups (Table - 2).