Results
In the present study, a total of 76 patients were screened. Ten patients were excluded because four patients had secondary hypertension, three patients did not wish to participate in the study and three patients were not able to comprehend the tests for memory and psychomotor assessment. In the Telmisartan group 33 patients were enrolled. Out of 33 participants one participant discontinued the study due to personal reasons and two discontinued the treatment. In the Cilnidipine group 33 patients were enrolled. Out of 33 participants two discontinued the treatment and one patient was lost to follow up. So in final analysis 60 participants were evaluated, 30 in each group (Figure - 1). No patient was disqualified due to non-response to study drugs at one month. Thirty-five were males and 25 were females. The mean age of patients was 45.13 ± 5.2 years. Demographic data is given in table - 1.Primary Outcomes: 1. Effects on Memory:Remote Memory and Recent memory scores: There was a significant improvement in Telmisartan group (p < 0.05) in remote and recent memory scores at the end of study compared to baseline. The mean percentage increase of remote memory score was 5.53 % and in recent memory was 3.66%. No significant improvement was observed in Cilnidipine group. The mean percentage increase of remote memory score was 5.21 % and was 2.82 % after three months. The actual values were given in Table - 2. There was no significant improvement in remote and recent memory scores between Telmisartan and Cilnidipine groups.Mental balance scores: There was no significant improvement in mental balance scores at the end of the study in both study groups as well as between the groups (Table - 2).Attention and concentration scores: Both the study groups showed a significant (p < 0.05) improvement in attention and concentration score after three months compared to baseline. The mean percentage increase was 4.95 % in Telmisartan group and 4.86% in Cilnidipine group. No significant improvement in was observed between Telmisartan and Cilnidipine group at three months (Table - 2).Visual retention test: There was an improvement in visual retention score in Cilnidipine group (0.86 %) after three months, which was statistically not significant. In Telmisartan group, a decrease of visual retention score (1.79%) was observed at the end of the study, which was also not statistically significant (Table - 2). Cilnidipine significantly (P < 0.05) improved Visual retention score when compared to Telmisartan at the end of study (Figure - 2).            No significant improvement was observed in delayed recall, Immediate recall, verbal retention of similar pairs, verbal retention of dissimilar pairs and Visual Recognition scores at the end of the study in both the study groups as well as between the groups (Table - 2).