Figure legends.
Figure 1. The TMB comparison between primary and metastasis. A:
The coexisting gene mutation in metastasis lesions (blue point) was more
than that in primary tumors (gray point) (P < 0.05,Q <0.05). B: The TMB score comparison between 731
primary cases and 930 metastasis cases ( P = 0.024).
Figure 2. Effect of tumor mutational burden on survival after
ICIs treatment. A: Survival curves for patients whose tissues from the
primary tumors between the high TMB (n =357) and the low TMB (n=369)
basing on the median cutoff value (5.58) (P = 0.486). B: Survival
curves for patients whose tissues from the metastasis lesions between
the high TMB (n = 539) and the low TMB (n = 389) basing on the median
cutoff value (P < 0.001). C: Survival curves for NSCLC
patients whose tissues from the primary tumors between the high TMB (n =
49) and the low TMB (n = 122) basing on the cutoff value = 10 (P= 0.474). D: Survival curves for NSCLC patients whose tissues from the
metastasis lesions between the high TMB (n = 68) and the low TMB (n =
111) basing on the cutoff value = 10 (P = 0.012). E: Survival
curves for patients whose tissues from the primary tumors between the
high TMB (n = 73) and the low TMB (n = 653) basing on the optimal cutoff
value = 20.19 in pan-cancer types (P < 0.001). F:
Survival curves for patients whose tissues from the metastasis lesions
between the high TMB (n = 289) and the low TMB (n = 639) basing on the
optimal cutoff value = 10.82 in pan-cancer types (P <
0.001).
Figure 1.