Figure legends.
Figure 1. The TMB comparison between primary and metastasis. A: The coexisting gene mutation in metastasis lesions (blue point) was more than that in primary tumors (gray point) (P < 0.05,Q <0.05). B: The TMB score comparison between 731 primary cases and 930 metastasis cases ( P = 0.024).
Figure 2. Effect of tumor mutational burden on survival after ICIs treatment. A: Survival curves for patients whose tissues from the primary tumors between the high TMB (n =357) and the low TMB (n=369) basing on the median cutoff value (5.58) (P = 0.486). B: Survival curves for patients whose tissues from the metastasis lesions between the high TMB (n = 539) and the low TMB (n = 389) basing on the median cutoff value (P < 0.001). C: Survival curves for NSCLC patients whose tissues from the primary tumors between the high TMB (n = 49) and the low TMB (n = 122) basing on the cutoff value = 10 (P= 0.474). D: Survival curves for NSCLC patients whose tissues from the metastasis lesions between the high TMB (n = 68) and the low TMB (n = 111) basing on the cutoff value = 10 (P = 0.012). E: Survival curves for patients whose tissues from the primary tumors between the high TMB (n = 73) and the low TMB (n = 653) basing on the optimal cutoff value = 20.19 in pan-cancer types (P < 0.001). F: Survival curves for patients whose tissues from the metastasis lesions between the high TMB (n = 289) and the low TMB (n = 639) basing on the optimal cutoff value = 10.82 in pan-cancer types (P < 0.001).
Figure 1.