Characteristics
|
1989-1994
|
1995-1998
|
1999-2002
|
2003-2006
|
2007-2010
|
2011-2014
|
2015-2019
|
P-value
|
Trials, No.
|
7
|
4
|
11
|
25
|
20
|
32
|
35
|
NA
|
Total participants, No.
|
5767
|
2680
|
6602
|
11713
|
24272
|
68504
|
29624
|
NA
|
Participants per trial, median (IQR)
|
846.3 (378-1330)
|
796.5 (43-1044)
|
136 (20-4060)
|
137 (29-6706)
|
163.5(49-18113)
|
229(41-21026)
|
238 (21-6351)
|
0.54
|
Weighted age, mean (SD)
|
69.5 (3.2)
|
70.5 (3.8)
|
67.4 (5.0)
|
62.3 (10.1)
|
62.8 (10.1)
|
64.2 (9.9)
|
64.4 (5.7)
|
0.24
|
Weighted women, No. (%)
|
26.2
|
44.5
|
42.7
|
35.6
|
35.4
|
36.7
|
30.4
|
0.54
|
Trials reporting participants ≥ 75 yrs., No.
|
3
|
NR
|
NR
|
2
|
2
|
12
|
8
|
0.374
|
Total participants ≥75 yrs., No.
|
5767
|
NR
|
NR
|
11713
|
24272
|
68504
|
29624
|
NA
|
Participants ≥75 yrs., No. (%)
|
849 (14.7)
|
NR
|
NR
|
10764 (91.4)
|
159 (0.7)
|
23888(34.9)
|
4007(13.5)
|
0.136
|
Ethnicity/Race
|
|
|
|
|
|
|
|
|
Trials reporting non-White, No.
|
NR
|
NR
|
NR
|
NR
|
3
|
6
|
7
|
NA
|
Non-Whites, No. (%)
|
NR
|
NR
|
NR
|
NR
|
5464 (36.0)
|
8483 (56.0)
|
1214 (8.0)
|
0.27
|
Trials reporting Blacks, No.
|
NR
|
NR
|
NR
|
NR
|
2
|
5
|
7
|
NA
|
Blacks, No. (%)
|
NR
|
NR
|
NR
|
NR
|
178 (18.3)
|
559 (57.5)
|
235 (24.2)
|
0.34
|
Trials reporting Asians, No.
|
NR
|
NR
|
NR
|
NR
|
2
|
7
|
6
|
NA
|
Asians, No. (%)
|
NR
|
NR
|
NR
|
NR
|
2786 (25.8)
|
7387 (68.3)
|
642 (5.9)
|
0.21
|
Trials reporting native Hawaiian or Pacific Islanders, No.
|
NR
|
NR
|
NR
|
NR
|
NR
|
3
|
1
|
NA
|
Native Hawaiian or Pacific Islanders, No. (%)
|
NR
|
NR
|
NR
|
NR
|
NR
|
10 (90.1)
|
1 (9.1)
|
0.22
|
Trials reporting American Indian or Alaskan
|
NR
|
NR
|
NR
|
NR
|
1
|
3
|
2
|
NA
|
Natives, No.
|
|
|
|
|
|
|
|
|
American Indian or Alaskan Native, No. (%)
|
NR
|
NR
|
NR
|
NR
|
1 (1.2)
|
63 (76.8)
|
18 (22.0)
|
0.71
|
Trials reporting Hispanics, No.
|
NR
|
NR
|
NR
|
NR
|
2
|
3
|
6
|
NA
|