Non-Pharmaceutical modulation of TDP-43

Excercise  explain
Stem-cell therapy  explain
antisense oligonucleotides  
TDP-43's cytoplasm sequestering in ALS and frontaltemporal dementia is associated with co-aggregation of TDP-43 with poly glycine-arginine protein poly(GR) and it is to the repeat expansion region of the poly(GR) protein, that antisense oligonuleotides have been targeted \cite{Nagano2020}  
Therapeutics based on small molecule inhibitors
Small molecule inhibitors that block accumulation of ALS-associated RNA-binding proteins (RBPs) such as TDP-43 from accumulating in stress granules in the brain of ALS/FTD patients (Neuron Volume 103, Issue 5, 4 September 2019, Pages 802-819).