Complementary and alternative medicine (CAM) approaches for the treatment of ALS
Withania somnifera (animal)
Huolingshengji Formula (HLSJ) Clinical 200 ml, p.o., 12 weeks
Dihuang Yinzi (DHYZ): Clinical Decoction, p.o., twice daily, 12 years Dihuang Yinzi, a Classical Chinese Herbal Prescription, for Amyotrophic Lateral Sclerosis: A 12-Year Follow-up Case Report(Cai & Yang, 2019)
Berberine may have therapeutic value in ALS. Berberine is an mTOR inhibitor that increases autophagy. As autophagy is the major mechanism by which pathogenic TDP-43 aggregates are removed from the cell, it has been proposed as a possible target for ALS. (Chang et al., 2016)