Contribution to authorship
MC and YG designed the study. FS and JW wrote the first version of the manuscript. MC and JW recruited patents and collected samples and clinical follow-up. FS, YW, YW, YZ, FC performed sample preparation and sequencing experiments. LZ, QL, XC, YY, MC conducted bioinformatics analysis. MC, FS, JW, and YG interpreted sequencing results and clinical implications. MC, DC and YG overviewed the study, finalized the manuscript, and provided funding.