Contribution to authorship
MC and YG designed the study. FS and JW wrote the first version of the
manuscript. MC and JW recruited patents and collected samples and
clinical follow-up. FS, YW, YW, YZ, FC performed sample preparation and
sequencing experiments. LZ, QL, XC, YY, MC conducted bioinformatics
analysis. MC, FS, JW, and YG interpreted sequencing results and clinical
implications. MC, DC and YG overviewed the study, finalized the
manuscript, and provided funding.