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ANTI-MÜLLERIAN HORMONE LEVELS AS A PREDICTOR OF FEMALE GENERAL HEALTH STATUS: A CROSS-SECTIONAL STUDY
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  • Antonio Quartucci,
  • Enrico Papaleo,
  • Laura Privitera,
  • Agnese Rebecchi,
  • Alessia Limena,
  • Maria Longo,
  • Eugenia Alleva,
  • Eugenio Ventimiglia,
  • Paola VIGANO,
  • Massimo Candiani,
  • Andrea Salonia,
  • Valeria Vanni
Antonio Quartucci
San Raffaele Hospital
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Enrico Papaleo
San Raffaele Hospital
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Laura Privitera
San Raffaele Hospital
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Agnese Rebecchi
San Raffaele Hospital
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Alessia Limena
Università Vita Salute San Raffaele
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Maria Longo
Università Vita Salute San Raffaele
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Eugenia Alleva
Università Vita Salute San Raffaele
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Eugenio Ventimiglia
San Raffaele Hospital
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Paola VIGANO
San Raffaele Hospital
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Massimo Candiani
San Raffaele Hospital
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Andrea Salonia
San Raffaele Hospital
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Valeria Vanni
San Raffaele Hospital
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Abstract

Objective: To assess the correlations between clinical and hormonal parameters and comorbidity burden in Caucasian women presenting for fertility treatment. Design: Cross-sectional study. Setting: Single academic reproductive medicine center. Patient: Cohort of 3163 single-ethnicity women seeking medical help for fertility treatment, who underwent centralized lab testing for fertility-related hormonal assessment. Intervention: Complete clinical and laboratory data from the entire cohort of patients were retrospectively analysed. Main outcome measures: Assessment of i) the comorbidity burden scored via the Charlson Comorbidity Index (CCI; categorized as 0 vs. 1 vs. >2); and, ii) the potential associations between CCI and clinical and hormonal parameters. Results: Descriptive statistics and regression models tested the associations between clinical and laboratory parameters and CCI. Of 3163, CCI=0, CCI=1 and CCI>2 were found in 2977 (94.1%), 113 (3.6%) and 73 (2.3%) patients, respectively. Age, gravidity, Anti-Müllerian hormone (AMH) and thyroid stimulating hormone (TSH) values were found to be significantly different among CCI groups (all p≤ 0.01). At regression models, age at presentation and AMH emerged as independent predictors of CCI>1. Age at presentation <36 years (OR=1.742, 95% CI [1.284; 2.364]) and an AMH level <2.3 ng/ml (OR=1.864, 95% CI [1.29; 2.69]) were the most informative cutoff values for CCI >1. Conclusions: A younger age at presentation and lower AMH levels are significant predictors of decreased general health in women requiring clinical evaluation for fertility treatment. As observed for sperm parameters in men, AMH might serve as a proxy of women’s general health status. Key words: AMH, comorbidities, health, infertility