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Ontogeny of drug metabolism and transport: new data derived by innovative approaches
  • +1
  • Bianca van Groen,
  • Karel Allegaert,
  • Dick Tibboel,
  • Saskia De wildt
Bianca van Groen
Erasmus MC - Sophia Children's Hospital
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Karel Allegaert
KU Leuven
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Dick Tibboel
Erasmus MC - Sophia Children's Hospital
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Saskia De wildt
Radboud Institute of Health Sciences, Radboud University Medical Center
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Peer review status:IN REVISION

29 Apr 2020Submitted to British Journal of Clinical Pharmacology
30 Apr 2020Assigned to Editor
30 Apr 2020Submission Checks Completed
04 May 2020Reviewer(s) Assigned
18 May 2020Review(s) Completed, Editorial Evaluation Pending
24 May 2020Editorial Decision: Revise Major

Abstract

Drug disposition in children is impacted by developmental changes in drug absorption, distribution, metabolism and excretion. This mandates the need for dosing regimens specifically tailored to children. Yet, there are gaps in the knowledge on these developmental changes, for example regarding hepatic and renal drug transport and drug metabolism, putting children at risk for subtherapeutic or toxic drug exposure. Pediatric drug research is faced with ethical and analytical challenges. This review addresses how these knowledge gaps can be filled and challenges can be overcome by using innovative study designs.