10. References
Abaffy, T., Bain, J. R., Muehlbauer, M. J., Spasojevic, I., Lodha, S.,
Bruguera, E.,… & Matsunami, H. (2018). A testosterone metabolite
19-hydroxyandrostenedione induces neuroendocrine trans-differentiation
of prostate cancer cells via an ectopic olfactory
receptor. Frontiers in Oncology , 8 , 162.
Abaffy, T., Matsunami, H., & Luetje, C. W. (2006). Functional analysis
of a mammalian odorant receptor subfamily. Journal of
neurochemistry , 97 (5), 1506-1518.
Adipietro, K. A., Mainland, J. D., & Matsunami, H. (2012). Functional
evolution of mammalian odorant receptors. PLoS
genetics , 8 (7).
Aisenberg, W. H., Huang, J., Zhu, W., Rajkumar, P., Cruz, R., Santhanam,
L., … & Yoon, A. R. (2016). Defining an olfactory receptor function
in airway smooth muscle cells. Scientific reports , 6 ,
38231.
Ali, B., Al-Wabel, N. A., Shams, S., Ahamad, A., Khan, S. A., & Anwar,
F. (2015). Essential oils used in aromatherapy: A systemic
review. Asian Pacific Journal of Tropical
Biomedicine , 5 (8), 601-611.
Alok, K., Rakesh, T., & Sushil, K. (2000). Aromatherapy-an alternative
health care through essential oils. Journal of Medicinal and
Aromatic Plant Sciences , 22 (1B), 798-804.
Angelucci, F. L., Silva, V. V., Dal Pizzol, C., Spir, L. G., Praes, C.
E. O., & Maibach, H. (2014). Physiological effect of olfactory stimuli
inhalation in humans: An overview. International journal of
cosmetic science , 36 (2), 117-123.
Ansoleaga, B., Garcia-Esparcia, P., Llorens, F., Moreno, J., Aso, E., &
Ferrer, I. (2013). Dysregulation of brain olfactory and taste receptors
in AD, PSP and CJD, and AD-related
model. Neuroscience , 248 , 369-382.
Ansoleaga, B., Garcia-Esparcia, P., Pinacho, R., Haro, J. M., Ramos, B.,
& Ferrer, I. (2015). Decrease in olfactory and taste receptor
expression in the dorsolateral prefrontal cortex in chronic
schizophrenia. Journal of psychiatric research , 60 ,
109-116.
Barros-Silva, J. D., Paulo, P., Bakken, A. C., Cerveira, N., Løvf, M.,
Henrique, R., … & Teixeira, M. R. (2013). Novel 5′ fusion partners of
ETV1 and ETV4 in prostate cancer. Neoplasia (New York,
NY) , 15 (7), 720.
Bezprozvanny, I., Scheller, R. H., & Tsien, R. W. (1995). Functional
impact of syntaxin on gating of N-type and Q-type calcium
channels. Nature , 378 (6557), 623-626.
Blowman, K., Magalhães, M., Lemos, M. F. L., Cabral, C., & Pires, I. M.
(2018). Anticancer properties of essential oils and other natural
products. Evidence-Based Complementary and Alternative
Medicine , 2018 .
Braun, T., Voland, P., Kunz, L., Prinz, C., & Gratzl, M. (2007).
Enterochromaffin cells of the human gut: sensors for spices and
odorants. Gastroenterology , 132 (5), 1890-1901.
Breer, H. (2003). Olfactory receptors: molecular basis for recognition
and discrimination of odors. Analytical and bioanalytical
chemistry , 377 (3), 427-433.
Brenker, C., Goodwin, N., Weyand, I., Kashikar, N. D., Naruse, M.,
Krähling, M., … & Strünker, T. (2012). The CatSper channel: a
polymodal chemosensor in human sperm. The EMBO
journal , 31 (7), 1654-1665.
Brown, S. G., Publicover, S. J., Barratt, C. L., & Martins da Silva, S.
J. (2019). Human sperm ion channel (dys) function: implications for
fertilization. Human reproduction update , 25 (6), 758-776.
Buck, L. B. (2000). The molecular architecture of odor and pheromone
sensing in mammals. Cell , 100 (6), 611-618.
Buck, L., & Axel, R. (1991). A novel multigene family may encode
odorant receptors: a molecular basis for odor
recognition. Cell , 65 (1), 175-187.
Busse, D., Kudella, P., Grüning, N. M., Gisselmann, G., Ständer, S.,
Luger, T., … & Böhm, M. (2014). A synthetic sandalwood odorant
induces wound-healing processes in human keratinocytes via the olfactory
receptor OR2AT4. Journal of investigative
dermatology , 134 (11), 2823-2832.
Cao, W., Li, F., Yao, J., & Yu, J. (2015). Prostate specific G protein
coupled receptor is associated with prostate cancer prognosis and
affects cancer cell proliferation and invasion. BMC
cancer , 15 (1), 915.
Chan, H. K., Hersperger, F., Marachlian, E., Smith, B. H., Locatelli,
F., Szyszka, P., & Nowotny, T. (2018). Odorant mixtures elicit less
variable and faster responses than pure odorants. PLoS
computational biology , 14 (12), e1006536.
Chéret, J., Bertolini, M., Ponce, L., Lehmann, J., Tsai, T., Alam, M.,
… & Paus, R. (2018). Olfactory receptor OR2AT4 regulates human hair
growth. Nature communications , 9 (1), 1-12.
Clark, A. A., Nurmukhambetova, S., Li, X., Munger, S. D., & Lees, J. R.
(2016). Odorants specifically modulate chemotaxis and tissue retention
of CD4+ T cells via cyclic adenosine monophosphate
induction. Journal of leukocyte biology , 100 (4), 699-709.
Costa, C. G., Dorland, L., Holwerda, U., De Almeida, I. T., Jakobs, C.,
& Duran, M. (1998). Simultaneous analysis of plasma free fatty acids
and their 3-hydroxy analogs in fatty acid β-oxidation
disorders. Clinical chemistry , 44 (3), 463-471.
Cui, T., Tsolakis, A. V., Li, S. C., Cunningham, J. L., Lind, T., Öberg,
K., & Giandomenico, V. (2013). Olfactory receptor 51E1 protein as a
potential novel tissue biomarker for small intestine neuroendocrine
carcinomas. European journal of endocrinology , 168 (2),
253-261.
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019). The
role of short-chain fatty acids in microbiota–gut–brain
communication. Nature Reviews Gastroenterology & Hepatology , 1.
Dalton, R. P., & Lomvardas, S. (2015). Chemosensory receptor
specificity and regulation. Annual review of
neuroscience , 38 , 331-349.
Denda, M., Tsuchiya, T., Shoji, K., & Tanida, M. (2000). Odorant
inhalation affects skin barrier homeostasis in mice and
humans. British Journal of Dermatology , 142 (5), 1007-1010.
Dhingra, D., Michael, M., Rajput, H., & Patil, R. T. (2012). Dietary
fibre in foods: a review. Journal of food science and
technology , 49 (3), 255-266.
Di Pizio, A., Behrens, M., & Krautwurst, D. (2019). Beyond the flavour:
the potential druggability of chemosensory G Protein-Coupled
receptors. International journal of molecular
sciences , 20 (6), 1402.
Digby, G. J., Lober, R. M., Sethi, P. R., & Lambert, N. A. (2006). Some
G protein heterotrimers physically dissociate in living
cells. Proceedings of the National Academy of
Sciences , 103 (47), 17789-17794.
Durzyński, Ł., Gaudin, J. C., Myga, M., Szydłowski, J.,
Goździcka-Józefiak, A., & Haertlé, T. (2005). Olfactory-like receptor
cDNAs are present in human lingual cDNA libraries. Biochemical and
biophysical research communications , 333 (1), 264-272.
Edwards, P. A., & Ericsson, J. (1999). Sterols and isoprenoids:
signaling molecules derived from the cholesterol biosynthetic
pathway. Annual review of biochemistry , 68 (1), 157-185.
Feldmesser, E., Olender, T., Khen, M., Yanai, I., Ophir, R., & Lancet,
D. (2006). Widespread ectopic expression of olfactory receptor
genes. BMC genomics , 7 (1), 121.
Ferrer, I., Garcia-Esparcia, P., Carmona, M., Carro, E., Aronica, E.,
Kovacs, G. G., … & Gustincich, S. (2016). Olfactory receptors in
non-chemosensory organs: the nervous system in health and
disease. Frontiers in aging neuroscience , 8 , 163.
Firestein, S. (2001). How the olfactory system makes sense of
scents. Nature 413 (6852), 211-218.
Flegel, C., Manteniotis, S., Osthold, S., Hatt, H., & Gisselmann, G.
(2013). Expression profile of ectopic olfactory receptors determined by
deep sequencing. PloS one , 8 (2).
Flegel, C., Vogel, F., Hofreuter, A., Schreiner, B. S., Osthold, S.,
Veitinger, S., … & Altmüller, J. (2016). Characterization of the
olfactory receptors expressed in human spermatozoa. Frontiers in
molecular biosciences , 2 , 73.
Frank, M., Thümer, L., Lohse, M. J., & Bünemann, M. (2005). G protein
activation without subunit dissociation depends on a Gαi-specific
region. Journal of biological Chemistry , 280 (26),
24584-24590.
Fujita, Y., Takahashi, T., Suzuki, A., Kawashima, K., Nara, F., &
Koishi, R. (2007). Deorphanization of Dresden G protein-coupled receptor
for an odorant receptor. Journal of Receptors and Signal
Transduction , 27 (4), 323-334.
Gainetdinov, R. R., Hoener, M. C., & Berry, M. D. (2018). Trace amines
and their receptors. Pharmacological reviews , 70 (3),
549-620.
Garcia-Esparcia, P., Schlüter, A., Carmona, M., Moreno, J., Ansoleaga,
B., Torrejón-Escribano, B., … & Ferrer, I. (2013). Functional
genomics reveals dysregulation of cortical olfactory receptors in
Parkinson disease: novel putative chemoreceptors in the human
brain. Journal of Neuropathology & Experimental
Neurology , 72 (6), 524-539.
Geithe, C., Andersen, G., Malki, A., & Krautwurst, D. (2015). A butter
aroma recombinate activates human class-I odorant
receptors. Journal of agricultural and food
chemistry , 63 (43), 9410-9420.
Gelis, L., Jovancevic, N., Bechara, F. G., Neuhaus, E. M., & Hatt, H.
(2017). Functional expression of olfactory receptors in human primary
melanoma and melanoma metastasis. Experimental
dermatology , 26 (7), 569-576.
Gelis, L., Jovancevic, N., Veitinger, S., Mandal, B., Arndt, H. D.,
Neuhaus, E. M., & Hatt, H. (2016). Functional characterization of the
odorant receptor 51E2 in human melanocytes. Journal of Biological
Chemistry , 291 (34), 17772-17786.
Giandomenico, V., Cui, T., Grimelius, L., Öberg, K., Pelosi, G., &
Tsolakis, A. V. (2013). Olfactory Receptor 51E1 as a Novel Target for
Diagnosis in Somatostatin Receptor Negative Lung
Carcinoids. Journal of molecular endocrinology , 51 ,
277-286.
Glusman, G., Bahar, A., Sharon, D., Pilpel, Y., White, J., & Lancet, D.
(2000). The olfactory receptor gene superfamily: data mining,
classification, and nomenclature. Mammalian
genome , 11 (11), 1016-1023.
Glusman, G., Yanai, I., Rubin, I., & Lancet, D. (2001). The complete
human olfactory subgenome. Genome research , 11 (5),
685-702.
Goldstein, J. L., & Brown, M. S. (1990). Regulation of the mevalonate
pathway. Nature , 343 (6257), 425-430.
Griffin, C. A., Kafadar, K. A., & Pavlath, G. K. (2009). MOR23 promotes
muscle regeneration and regulates cell adhesion and
migration. Developmental cell , 17 (5), 649-661.
Grison, A., Zucchelli, S., Urzì, A., Zamparo, I., Lazarevic, D.,
Pascarella, G., … & Simone, R. (2014). Mesencephalic dopaminergic
neurons express a repertoire of olfactory receptors and respond to
odorant-like molecules. BMC genomics , 15 (1), 729.
Gu X. & Ben-Shahar Y. (2013) Olfactory Receptors in Human Airway
Epithelia. In: Crasto C. (eds) Olfactory Receptors. Methods in Molecular
Biology (Methods and Protocols), vol 1003. Humana Press, Totowa, NJ.
Gu, X., Karp, P. H., Brody, S. L., Pierce, R. A., Welsh, M. J.,
Holtzman, M. J., & Ben-Shahar, Y. (2014). Chemosensory functions for
pulmonary neuroendocrine cells. American journal of respiratory
cell and molecular biology , 50 (3), 637-646.
Guleria, S., Tiku, A. K., Koul, A., Gupta, S., Singh, G., & Razdan, V.
K. (2013). Antioxidant and antimicrobial properties of the essential oil
and extracts of Zanthoxylum alatum grown in North-Western
Himalaya. The Scientific World Journal , 2013 .
Hartmann, C., Triller, A., Spehr, M., Dittrich, R., Hatt, H., &
Buettner, A. (2013). Sperm‐Activating Odorous Substances in Human
Follicular Fluid and Vaginal Secretion: Identification by Gas
Chromatography–Olfactometry and Ca2+Imaging. ChemPlusChem , 78 (7), 695-702.
Hetherington-Rauth, M. C., & Ramírez, S. R. (2016). Evolution and
diversity of floral scent chemistry in the euglossine bee-pollinated
orchid genus Gongora. Annals of botany , 118 (1), 135-148.
Hutchings, C. J., Koglin, M., Olson, W. C., & Marshall, F. H. (2017).
Opportunities for therapeutic antibodies directed at G-protein-coupled
receptors. Nature reviews Drug discovery , 16 (11), 787.
Itakura, S., Ohno, K., Ueki, T., Sato, K., & Kanayama, N. (2006).
Expression of Golf in the rat placenta: Possible implication in
olfactory receptor transduction. Placenta , 27 (1), 103-108.
Jimbo, D., Kimura, Y., Taniguchi, M., Inoue, M., & Urakami, K. (2009).
Effect of aromatherapy on patients with Alzheimer’s
disease. Psychogeriatrics , 9 (4), 173-179.
Jones, D. T., & Reed, R. R. (1989). Golf: an olfactory neuron
specific-G protein involved in odorant signal
transduction. Science , 244 (4906), 790-795.
Jovancevic, N., Dendorfer, A., Matzkies, M., Kovarova, M., Heckmann, J.
C., Osterloh, M., … & Hescheler, J. (2017a). Medium-chain fatty acids
modulate myocardial function via a cardiac odorant receptor. Basic
research in cardiology , 112 (2), 13.
Jovancevic, N., Wunderlich, K. A., Haering, C., Flegel, C., Maßberg, D.,
Weinrich, M., … & Wolfrum, U. (2017b). Deep sequencing of the human
retinae reveals the expression of odorant receptors. Frontiers in
cellular neuroscience , 11 , 3.
Kaji, I., Karaki, S. I., & Kuwahara, A. (2011). Effects of luminal
thymol on epithelial transport in human and rat colon. American
Journal of Physiology-Gastrointestinal and Liver
Physiology , 300 (6), G1132-G1143.
Kako, H., Fukumoto, S., Kobayashi, Y., & Yokogoshi, H. (2008). Effects
of direct exposure of green odour components on dopamine release from
rat brain striatal slices and PC12 cells. Brain research
bulletin , 75 (5), 706-712.
Kalbe, B., Knobloch, J., Schulz, V. M., Wecker, C., Schlimm, M., Scholz,
P., … & Lübbert, H. (2016a). Olfactory receptors modulate
physiological processes in human airway smooth muscle
cells. Frontiers in physiology , 7 , 339.
Kalbe, B., Schlimm, M., Mohrhardt, J., Scholz, P., Jansen, F., Hatt, H.,
& Osterloh, S. (2016b). Helional induces Ca2+decrease and serotonin secretion of QGP-1 cells via a PKG-mediated
pathway. J. Mol. Endocrinol , 57 , 201-210.
Kalbe, B., Schlimm, M., Wojcik, S., Philippou, S., Maßberg, D., Jansen,
F., … & Hatt, H. (2016c). Olfactory signaling components and
olfactory receptors are expressed in tubule cells of the human
kidney. Archives of biochemistry and biophysics , 610 ,
8-15.
Kalbe, B., Schulz, V. M., Schlimm, M., Philippou, S., Jovancevic, N.,
Jansen, F., … & Hecker, E. (2017). Helional-induced activation of
human olfactory receptor 2J3 promotes apoptosis and inhibits
proliferation in a non-small-cell lung cancer cell line. European
journal of cell biology , 96 (1), 34-46.
Kaupp, U. B. (2010). Olfactory signalling in vertebrates and insects:
differences and commonalities. Nature Reviews
Neuroscience , 11 (3), 188-200.
Kaupp, U. B., Niidome, T., Tanabe, T., Terada, S., Bönigk, W., Stühmer,
W., … & Miyata, T. (1989). Primary structure and functional
expression from complementary DNA of the rod photoreceptor cyclic
GMP-gated channel. Nature , 342 (6251), 762-766.
Kim, S. H., Yoon, Y. C., Lee, A. S., Kang, N., Koo, J., Rhyu, M. R., &
Park, J. H. (2015). Expression of human olfactory receptor 10J5 in heart
aorta, coronary artery, and endothelial cells and its functional role in
angiogenesis. Biochemical and biophysical research
communications , 460 (2), 404-408.
Koyano, S., Emi, M., Saito, T., Makino, N., Toriyama, S., Ishii, M., …
& Kawata, S. (2008). Common null variant, Arg192Stop, in a G‐protein
coupled receptor, olfactory receptor 1B1, associated with decreased
serum cholinesterase activity. Hepatology Research , 38 (7),
696-703.
Lahlou, M. (2004). Essential oils and fragrance compounds: bioactivity
and mechanisms of action. Flavour and Fragrance
Journal , 19 (2), 159-165.
Lee, S. J., Depoortere, I., & Hatt, H. (2019). Therapeutic potential of
ectopic olfactory and taste receptors. Nature Reviews Drug
Discovery , 18 (2), 116-138.
Leja, J., Essaghir, A., Essand, M., Wester, K., Tötterman, T. H., Lloyd,
R., … & Giandomenico, V. (2009). Novel markers for enterochromaffin
cells and gastrointestinal neuroendocrine carcinomas. Modern
pathology , 22 (2), 261-272.
Li, Y. R., & Matsunami, H. (2011). Activation state of the M3
muscarinic acetylcholine receptor modulates mammalian odorant receptor
signaling. Science signaling , 4 (155), ra1-ra1.
Locatelli, F. F., Fernandez, P. C., & Smith, B. H. (2016). Learning
about natural variation of odor mixtures enhances categorization in
early olfactory processing. Journal of Experimental
Biology , 219 (17), 2752-2762.
Luu, P., Acher, F., Bertrand, H. O., & Ngai, J. (2005). Odorant
receptor specificities and receptor combinatorials: implications for
olfactory coding. Chemical senses , 30 (suppl_1), i97-i98.
Ma, X., Guan, L., Wu, W., Zhang, Y., Zheng, W., Gao, Y. T., … & Xu,
B. (2015). Whole-exome sequencing identifies OR2W3 mutation as a cause
of autosomal dominant retinitis pigmentosa. Scientific
reports , 5 (1), 1-6.
Macfarlane, S., & Macfarlane, G. T. (2003). Regulation of short-chain
fatty acid production. Proceedings of the Nutrition
Society , 62 (1), 67-72.
Mainland, J. D., Li, Y. R., Zhou, T., Liu, W. L. L., & Matsunami, H.
(2015). Human olfactory receptor responses to odorants. Scientific
data , 2 (1), 1-9.
Malik, B., Elkaddi, N., Turkistani, J., Spielman, A. I., & Ozdener, M.
H. (2019). Mammalian Taste Cells Express Functional Olfactory
Receptors. Chemical senses , 44 (5), 289-301.
Manteniotis, S., Wojcik, S., Brauhoff, P., Möllmann, M., Petersen, L.,
Göthert, J. R., … & Hatt, H. (2016a). Functional characterization of
the ectopically expressed olfactory receptor 2AT4 in human myelogenous
leukemia. Cell death discovery , 2 (1), 1-10.
Manteniotis, S., Wójcik, S., Göthert, J. R., Dürig, J., Dührsen, U.,
Gisselmann, G., & Hatt, H. (2016b). Deorphanization and
characterization of the ectopically expressed olfactory receptor OR51B5
in myelogenous leukemia cells. Cell death discovery , 2 (1),
1-9.
Masjedi, S., Zwiebel, L. J., & Giorgio, T. D. (2019). Olfactory
receptor gene abundance in invasive breast carcinoma. Scientific
reports , 9 (1), 1-12.
Maßberg, D., & Hatt, H. (2018). Human olfactory receptors: novel
cellular functions outside of the nose. Physiological
reviews , 98 (3), 1739-1763.
Maßberg, D., Jovancevic, N., Offermann, A., Simon, A., Baniahmad, A.,
Perner, S., … & Heiland, M. (2016). The activation of OR51E1 causes
growth suppression of human prostate cancer
cells. Oncotarget , 7 (30), 48231.
Maßberg, D., Simon, A., Häussinger, D., Keitel, V., Gisselmann, G.,
Conrad, H., & Hatt, H. (2015). Monoterpene (−)-citronellal affects
hepatocarcinoma cell signaling via an olfactory receptor. Archives
of Biochemistry and Biophysics , 566 , 100-109.
Morita, R., Hirohashi, Y., Torigoe, T., Ito-Inoda, S., Takahashi, A.,
Mariya, T., … & Kubo, T. (2016). Olfactory Receptor Family 7
Subfamily C Member 1 Is a Novel Marker of Colon Cancer–Initiating Cells
and Is a Potent Target of Immunotherapy. Clinical Cancer
Research , 22 (13), 3298-3309.
Munakata, Y., Yamada, T., Imai, J., Takahashi, K., Tsukita, S., Shirai,
Y., Kodama, S., Asai, Y., Sugisawa, T., Chiba, Y. and Kaneko, K. (2018).
Olfactory receptors are expressed in pancreatic β-cells and promote
glucose-stimulated insulin secretion. Scientific
reports , 8 (1), pp.1-11.
Natarajan, N., & Pluznick, J. L. (2016). Olfaction in the
kidney:‘smelling’gut microbial metabolites. Experimental
physiology , 101 (4), 478-481.
Neuhaus, E. M., Mashukova, A., Barbour, J., Wolters, D., & Hatt, H.
(2006). Novel function of β-arrestin2 in the nucleus of mature
spermatozoa. Journal of cell science , 119 (15), 3047-3056.
Neuhaus, E. M., Zhang, W., Gelis, L., Deng, Y., Noldus, J., & Hatt, H.
(2009). Activation of an olfactory receptor inhibits proliferation of
prostate cancer cells. Journal of Biological
Chemistry , 284 (24), 16218-16225.
Oh, S. J. (2018). System-wide expression and function of olfactory
receptors in mammals. Genomics & informatics , 16 (1), 2.
Oldham, W. M., & Hamm, H. E. (2008). Heterotrimeric G protein
activation by G-protein-coupled receptors. Nature reviews
Molecular cell biology , 9 (1), 60-71.
Olender, T., Keydar, I., Pinto, J. M., Tatarskyy, P., Alkelai, A.,
Chien, M. S., … & Lancet, D. (2016). The human olfactory
transcriptome. BMC genomics , 17 (1), 619.
Ottaviano, G., Zuccarello, D., Menegazzo, M., Perilli, L., Marioni, G.,
Frigo, A. C., … & Foresta, C. (2013). Human olfactory sensitivity for
bourgeonal and male infertility: a preliminary
investigation. European Archives of
Oto-Rhino-Laryngology , 270 (12), 3079-3086.
Overington, J. P., Al-Lazikani, B., & Hopkins, A. L. (2006). How many
drug targets are there?. Nature reviews Drug
discovery , 5 (12), 993-996.
Parmentier, M., Libert, F., Schurmans, S., Schiffmann, S., Lefort, A.,
Eggerickx, D., … & Grootegoed, A. (1992). Expression of members of
the putative olfactory receptor gene family in mammalian germ
cells. Nature , 355 (6359), 453-455.
Perry, N., & Perry, E. (2006). Aromatherapy in the management of
psychiatric disorders. CNS drugs , 20 (4), 257-280.
Peterlin, Z., Firestein, S., & Rogers, M. E. (2014). The state of the
art of odorant receptor deorphanization: a report from the
orphanage. Journal of General Physiology , 143 (5), 527-542.
Pichavant, C., Burkholder, T. J., & Pavlath, G. K. (2015). Decrease of
myofiber branching via muscle-specific expression of the olfactory
receptor mOR23 in dystrophic muscle leads to protection against
mechanical stress. Skeletal muscle , 6 (1), 2.
Pichersky, E., Noel, J. P., & Dudareva, N. (2006). Biosynthesis of
plant volatiles: nature’s diversity and
ingenuity. Science , 311 (5762), 808-811.
Pick, H., Etter, S., Baud, O., Schmauder, R., Bordoli, L., Schwede, T.,
& Vogel, H. (2009). Dual activities of odorants on olfactory and
nuclear hormone receptors. Journal of biological
chemistry , 284 (44), 30547-30555.
Pluznick, J. L. (2013). Renal and cardiovascular sensory receptors and
blood pressure regulation. American Journal of Physiology-Renal
Physiology , 305 (4), F439-F444.
Pluznick, J. L. (2016). Gut microbiota in renal physiology: focus on
short-chain fatty acids and their receptors. Kidney
international , 90 (6), 1191-1198.
Ranzani, M., Iyer, V., Ibarra-Soria, X., Velasco-Herrera, M. D. C.,
Garnett, M., Logan, D., & Adams, D. J. (2017). Revisiting olfactory
receptors as putative drivers of cancer. Wellcome open
research , 2 .
Rigau, M., Morote, J., Mir, M. C., Ballesteros, C., Ortega, I., Sanchez,
A., … & Planas, J. (2010). PSGR and PCA3 as biomarkers for the
detection of prostate cancer in urine. The
Prostate , 70 (16), 1760-1767.
Rodriguez, M., Luo, W., Weng, J., Zeng, L., Yi, Z., Siwko, S., & Liu,
M. (2014). PSGR promotes prostatic intraepithelial neoplasia and
prostate cancer xenograft growth through
NF-κB. Oncogenesis , 3 (8), e114-e114.
Rooks, M. G., & Garrett, W. S. (2016). Gut microbiota, metabolites and
host immunity. Nature Reviews Immunology , 16 (6), 341-352.
Rouquier, S., Taviaux, S., Trask, B. J., Brand-Arpon, V., van den Engh,
G., Demaille, J., & Giorgi, D. (1998). Distribution of olfactory
receptor genes in the human genome. Nature
genetics , 18 (3), 243-250.
Saito, H., Chi, Q., Zhuang, H., Matsunami, H., & Mainland, J. D.
(2009). Odor coding by a Mammalian receptor repertoire. Science
signaling , 2 (60), ra9-ra9.
Santha, S., & Dwivedi, C. (2015). Anticancer effects of sandalwood
(Santalum album). Anticancer research , 35 (6), 3137-3145.
Sanz, G., Leray, I., Dewaele, A., Sobilo, J., Lerondel, S., Bouet, S.,
… & Mir, L. M. (2014). Promotion of cancer cell invasiveness and
metastasis emergence caused by olfactory receptor
stimulation. PloS one , 9 (1).
Sanz, G., Schlegel, C., Pernollet, J. C., & Briand, L. (2005).
Comparison of odorant specificity of two human olfactory receptors from
different phylogenetic classes and evidence for
antagonism. Chemical senses , 30 (1), 69-80.
Schiller, C., & Schiller, D. (1994). 500 formulas for
aromatherapy: mixing essential oils for every use. Sterling Publishing
Company, Inc, NY, USA.
Sharon, D., Kimchi, A., & Rivolta, C. (2016). OR2W3 sequence variants
are unlikely to cause inherited retinal diseases. Ophthalmic
genetics , 37 (4), 366-368.
Shepard, B. D., Cheval, L., Peterlin, Z., Firestein, S., Koepsell, H.,
Doucet, A., & Pluznick, J. L. (2016). A renal olfactory receptor aids
in kidney glucose handling. Scientific reports , 6 , 35215.
Shiina, Y., Funabashi, N., Lee, K., Toyoda, T., Sekine, T., Honjo, S.,
… & Murakami, S. (2008). Relaxation effects of lavender aromatherapy
improve coronary flow velocity reserve in healthy men evaluated by
transthoracic Doppler echocardiography. International journal of
cardiology , 129 (2), 193-197.
Sinding, C., Kemper, E., Spornraft-Ragaller, P., & Hummel, T. (2013).
Decreased perception of bourgeonal may be linked to male idiopathic
infertility. Chemical senses , 38 (5), 439-445.
Smith, C. A., Collins, C. T., Crowther, C. A., & Levett, K. M. (2011).
Acupuncture or acupressure for pain management in labour. Cochrane
Database of Systematic Reviews , (7).
Sondersorg, A. C., Busse, D., Kyereme, J., Rothermel, M., Neufang, G.,
Gisselmann, G., … & Conrad, H. (2014). Chemosensory information
processing between keratinocytes and trigeminal neurons. Journal
of Biological Chemistry , 289 (25), 17529-17540.
Spehr, J., Gelis, L., Osterloh, M., Oberland, S., Hatt, H., Spehr, M.,
& Neuhaus, E. M. (2011). G protein-coupled receptor signaling via Src
kinase induces endogenous human transient receptor potential vanilloid
type 6 (TRPV6) channel activation. Journal of Biological
Chemistry , 286 (15), 13184-13192.
Spehr, M., Gisselmann, G., Poplawski, A., Riffell, J. A., Wetzel, C. H.,
Zimmer, R. K., & Hatt, H. (2003). Identification of a testicular
odorant receptor mediating human sperm
chemotaxis. Science , 299 (5615), 2054-2058.
Sprang, S. R. (2007). A receptor
unlocked. Nature , 450 (7168), 355-356.
Strünker, T., Goodwin, N., Brenker, C., Kashikar, N. D., Weyand, I.,
Seifert, R., & Kaupp, U. B. (2011). The CatSper channel mediates
progesterone-induced Ca 2+ influx in human
sperm. Nature , 471 (7338), 382-386.
Tham, E. H., Dyjack, N., Kim, B. E., Rios, C., Seibold, M. A., Leung, D.
Y., & Goleva, E. (2019). Expression and function of the ectopic
olfactory receptor OR10G7 in patients with atopic
dermatitis. Journal of Allergy and Clinical
Immunology , 143 (5), 1838-1848.
Tong, T., Ryu, S. E., Min, Y., Claire, A., Bushdid, C., Golebiowski, J.,
… & Park, T. (2017). Olfactory receptor 10J5 responding to α-cedrene
regulates hepatic steatosis via the cAMP–PKA pathway. Scientific
reports , 7 (1), 1-13.
Tsai, T., Veitinger, S., Peek, I., Busse, D., Eckardt, J., Vladimirova,
D., … & Ständer, S. (2017). Two olfactory receptors—OR 2A4/7 and OR
51B5—differentially affect epidermal proliferation and
differentiation. Experimental dermatology , 26 (1), 58-65.
Veitinger, T., Riffell, J. R., Veitinger, S., Nascimento, J. M.,
Triller, A., Chandsawangbhuwana, C., … & Neuhaus, E. M. (2011).
Chemosensory Ca2+ dynamics correlate with diverse
behavioral phenotypes in human sperm. Journal of Biological
Chemistry , 286 (19), 17311-17325.
Wang, J., Weng, J., Cai, Y., Penland, R., Liu, M., & Ittmann, M.
(2006). The prostate‐specific G‐protein coupled receptors PSGR and PSGR2
are prostate cancer biomarkers that are complementary to
α‐methylacyl‐CoA racemase. The Prostate , 66 (8), 847-857.
Weber, L., Al-Refae, K., Ebbert, J., Jägers, P., Altmüller, J., Becker,
C., … & Hatt, H. (2017). Activation of odorant receptor in colorectal
cancer cells leads to inhibition of cell proliferation and
apoptosis. PLoS One , 12 (3).
Weber, L., Maßberg, D., Becker, C., Altmüller, J., Ubrig, B., Bonatz,
G., … & Gisselmann, G. (2018a). Olfactory receptors as biomarkers in
human breast carcinoma tissues. Frontiers in oncology , 8 ,
33.
Weber, L., Schulz, W. A., Philippou, S., Eckardt, J., Ubrig, B.,
Hoffmann, M. J., … & Hatt, H. (2018b). Characterization of the
olfactory receptor OR10H1 in human urinary bladder
cancer. Frontiers in physiology , 9 , 456.
Weng, J., Ma, W., Mitchell, D., Zhang, J., & Liu, M. (2005). Regulation
of human prostate‐specific G‐protein coupled receptor, PSGR, by two
distinct promoters and growth factors. Journal of cellular
biochemistry , 96 (5), 1034-1048.
Wennemuth, G., Carlson, A. E., Harper, A. J., & Babcock, D. F. (2003).
Bicarbonate actions on flagellar and Ca2+-channel
responses: initial events in sperm
activation. Development , 130 (7), 1317-1326.
Wiese, H., Gelis, L., Wiese, S., Reichenbach, C., Jovancevic, N.,
Osterloh, M., … & Warscheid, B. (2015). Quantitative
phosphoproteomics reveals the protein tyrosine kinase Pyk2 as a central
effector of olfactory receptor signaling in prostate cancer
cells. Biochimica et Biophysica Acta (BBA)-Proteins and
Proteomics , 1854 (6), 632-640.
Wildwood, C. (August 1, 1996). The encyclopedia of aromatherapy .
Healing Arts Press, Rochester VT, USA.
Wojcik, S., Weidinger, D., Ständer, S., Luger, T., Hatt, H., &
Jovancevic, N. (2018). Functional characterization of the extranasal OR
2A4/7 expressed in human melanocytes. Experimental
dermatology , 27 (11), 1216-1223.
Woodward, M. R., Amrutkar, C. V., Shah, H. C., Benedict, R. H.,
Rajakrishnan, S., Doody, R. S., … & Szigeti, K. (2017). Validation of
olfactory deficit as a biomarker of Alzheimer disease. Neurology:
Clinical Practice , 7 (1), 5-14.
Wu, C., Hwang, S. H., Jia, Y., Choi, J., Kim, Y. J., Choi, D., … &
Lee, S. J. (2017). Olfactory receptor 544 reduces adiposity by steering
fuel preference toward fats. The Journal of clinical
investigation , 127 (11), 4118-4123.
Wu, C., Jia, Y., Lee, J. H., Kim, Y., Sekharan, S., Batista, V. S., &
Lee, S. J. (2015). Activation of OR1A1 suppresses PPAR-γ expression by
inducing HES-1 in cultured hepatocytes. The international journal
of biochemistry & cell biology , 64 , 75-80.
Xia, C., Ma, W., Wang, F., Hua, S. B., & Liu, M. (2001). Identification
of a prostate-specific G-protein coupled receptor in prostate
cancer. Oncogene , 20 (41), 5903-5907.
Xu, L. L., Stackhouse, B. G., Florence, K., Zhang, W., Shanmugam, N.,
Sesterhenn, I. A., … & Carter, K. (2000). PSGR, a novel
prostate-specific gene with homology to a G protein-coupled receptor, is
overexpressed in prostate cancer. Cancer research , 60 (23),
6568-6572.
Xu, L. L., Sun, C., Petrovics, G., Makarem, M., Furusato, B., Zhang, W.,
… & Srivastava, S. (2006). Quantitative expression profile of PSGR in
prostate cancer. Prostate cancer and prostatic
diseases , 9 (1), 56-61.
Xu, L., Tang, H., Chen, D. W., El‐Naggar, A. K., Wei, P., & Sturgis, E.
M. (2015). Retracted: Genome‐wide association study identifies common
genetic variants associated with salivary gland carcinoma and its
subtypes. Cancer , 121 (14), 2367-2374.
Zhang, D., & Huang, X. (2015). Further consideration of the association
between OR2W3 mutation and retinitis pigmentosa. Investigative
ophthalmology & visual science , 56 (13), 8028-8028.
Zhao, W., Ho, L., Varghese, M., Yemul, S., Dams-O’Connor, K., Gordon,
W., … & Pasinetti, G. M. (2013). Decreased level of olfactory
receptors in blood cells following traumatic brain injury and potential
association with tauopathy. Journal of Alzheimer’s
Disease, 34(2), 417-429.