Objectives: The aim of current study was to appraise the relationship between women body image perception and depression in case and controls Methods: In this case-control study 60 polycystic ovarian syndrome patients established agreeing to Rotterdam criteria and 20 healthy controls of reproductive age group were enrolled. The PCOS patients and healthy controls were evaluated on questionnaire for physical appearance and depression. Body image perception was accessed using the validated Body Esteem Scale (Franzoi et al., 1984).The symptoms of Depression were evaluated with the Quick Inventory of Depressive Symptomatology-Self Report (Rush et al., 2003). Results: The groups were age matched therefore no significant disparities were detected (p>0.05). Additionally, significant change (p<0.05) was found of body image perception between cases and controls with vast majority of females declared that they have perceived a positive body image for themselves in both groups which depict a healthy mind frame. However, it was found that controls (those without PCO) were 96% less likely to have negative body image perception as compared to cases (those with PCO). Furthermore, 55% women in PCO group admitted of being depressed as compared to controls as insignificant (p>0.05) association was seen between depression and PCO status of the study subjects. Though PCOS (cases) have 2.27 times more odds to develop depression as compared to those without PCOS Conclusion: There was significant difference found of body image perception between case and controls. In addition, insignificant association was seen between depression and PCO status of study subjects. In addition, the probabilities of negative body image perception and depression were more present in PCOS than normal females. Therefore, health of the patients with the set of symptoms is essential to be acknowledged more fully, predominantly in relation to the despair and poor body image.

Aim & Objective: Silent information Regulators (SIRT1) gene stimulates the expression of antioxidants and repairs damaged cells. It affects the mitochondrial activity within the oocytes to overcome the oxidant stress. We aimed to assess an association of SIRT1 polymorphism (Tag SNPs rs10509291 and rs12778366) with fertility, and assess serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone, manganese superoxide (MnSOD) and SIRT1. Material and Methods: In this cross-sectional study, 207 fertile and 135 infertile subjects between the ages of 18-45 year were recruited. Polymerase chain reaction (PCR) was performed; products were electrophoresed in a 2% agarose gel. Descriptive analysis of continuous variables was expressed as mean ± standard deviation. Mann-Whitney test was performed for comparison of groups, p value <0.001 was considered significant. Single Nucleotide Polymorphism (SNP) data was analyzed by applying chi-squared statistics. Results: All subjects were age matched (p = 0.896). SIRT1 levels were significantly lower in infertile females when compared with fertile subjects (p<0.001). AA (rs10509291) and CC (rs12778366) variant frequency was higher in the infertile than fertile subjects (p<0.01). Similarly, the frequency of A allele (rs10509291) and C allele (rs12778366) was higher in infertile subjects (p<0.001). Infertile females (29%) showed existence of SNP rs10509291 while 49% demonstrated genetic variation of rs12778366. MnSOD and SIRT1 levels were found to be lower in these subjects. Conclusion: Presence of SIRT1 genetic variants (rs10509291 and rs12778366) apparently disturbs the expression of SIRT1 deteriorating mitochondrial antioxidant function within the oocytes, instigating oxidative stress within. Their probable effect on modulating oocyte maturation may be the cause of infertility in females.