Recurrence Results
Our data indicated that the duration of GnRH agonist therapy is highly
dependent upon the stage of endometriosis. Medical treatment is the
preferred option and a main advantage of this method appears to be the
elimination of residual lesions so that no spot remains leading to
regrowth.
In stage I, after three months of GnRH agonist therapy, a majority of
lesions disappeared in addition to the coagulation of endometriosis
spots to achieve complete recovery. In stages II and III, after the
first look diagnostic laparoscopy, GnRH agonist was injected for six and
nine months, respectively, and the prescription of the new dosage was
dependent upon the second observational laparoscopy following this
period. Interestingly, all stage I and II endometriosis patients cured
with 3- and 6-month GnRHa treatment, respectively, and there was no
report of recurrence after five years of follow up using OCP (Oral
Contraceptive Pill). However, in stages III endometriosis 6-month GnRHa
was not sufficient to eliminate all lesions but after 9 month most of
them disappear.