Recurrence Results
Our data indicated that the duration of GnRH agonist therapy is highly dependent upon the stage of endometriosis. Medical treatment is the preferred option and a main advantage of this method appears to be the elimination of residual lesions so that no spot remains leading to regrowth.
In stage I, after three months of GnRH agonist therapy, a majority of lesions disappeared in addition to the coagulation of endometriosis spots to achieve complete recovery. In stages II and III, after the first look diagnostic laparoscopy, GnRH agonist was injected for six and nine months, respectively, and the prescription of the new dosage was dependent upon the second observational laparoscopy following this period. Interestingly, all stage I and II endometriosis patients cured with 3- and 6-month GnRHa treatment, respectively, and there was no report of recurrence after five years of follow up using OCP (Oral Contraceptive Pill). However, in stages III endometriosis 6-month GnRHa was not sufficient to eliminate all lesions but after 9 month most of them disappear.