5 CONCLUSION
We have demonstrated that neonates were exposed to high rates of
off-label drug use in Henan, China. The most frequently prescribed
category of off-label use was anti-infectives for systemic use and most
frequently prescribed drugs in an off-label manner were phosphocreatine
and phylloquinone. Efforts are still in urgent need to ensure the safety
and efficiency of drug therapy for neonates, such as the publication and
implementation of guidelines, the clinical pharmacokinetic and
pharmacodynamic research, and the design and development of pediatric
formulations.