Variables Before treatment After treatment P-value*
Non-severe exacerbations, median (Q1; Q3) Change
5.0 (3.0; 8.0)a
1.0 (0.0; 2.0) −4.0 (−8.0; 2.0)
<0.0001
Pulmonary function (FEV1%), median (Q1; Q3) Change
69.0 (58.0;79.0)b
86.0 (80.0; 94.0)c 15.0 (5.0; 27.0)
<0.0001
Use of healthcare resources / absenteeism due to non-severe exacerbations, median (Q1; Q3) Unplanned visits to primary care Unplanned visits to specialists School or workplace absenteeism, days 5.0 (3.0; 8.0)d 2.0 (0.0; 4.0)c 2.0 (0.0; 15.0)e 0.0 (0.0; 1.0)b 0.0 (0.0; 0.5) 0.0 (0.0; 0.0)f - - <0.0001