Clinical evaluation of Li Brush endometrial samplers for diagnosing
endometrial lesions in women with intrauterine devices
Abstract
Objective: To investigate the feasibility and diagnostic accuracy of
endometrial biopsy using Li Brush sampler in IUD users. Design: Clinical
research Setting: A public teaching hospital in China. Population: IUD
users with irregular uterine bleeding and IUD non-users who arranged for
dilatation and curettage at the First Affiliated Hospital of Xi’an
Jiaotong University, China from January 2018 to January 2020. Methods:
This study was conducted in two parts. Part Ⅰ was to assess the impact
of Li Brush on the position of IUDs. Transvaginal ultrasound was used to
locate IUDs before and after sampling. Part Ⅱ was to explore the
diagnostic accuracy of Li Brush in detecting endometrial lesions. Both
IUD users and non-users were recruited, and the sampling satisfaction
and accuracy of Li Brush were evaluated. Main outcome Measures: The
positions of IUDs before and after sampling, cytopathological and
histopathological diagnosis, sampling satisfaction rate. Results:
Seventeen cases in part Ⅰ confirmed no significant difference in the
position of IUDs before and after sampling (p=0.20). 112 IUD users and
139 IUD non-users were recruited in part Ⅱ. The Li Brush achieved
94.64% and 92.09% sampling satisfaction in the IUD group and control
group, respectively, and the overall diagnostic accuracy was 88.04% and
93.33% in the two groups. Conclusions: Li Brush used for endometrial
biopsy did not affect the position of IUDs and had high sampling
satisfaction and accuracy for endometrial diagnoses.