Introduction
Synchronous and metachronous brain tumors (BT) are rare in children and present diagnostic and therapeutic challenges. Besides, malignant transformation (MT) in children is not a frequent occurrence1 and can be missed if a high index of suspicion is not present. In this report, we present 2 unique cases of synchronous BT and we elaborate on their presentation, diagnosis, approach to management, and outcome. The first case describes a unique and previously unreported combination of a supratentorial (ST) anaplastic ependymoma (EPN) and a cerebellar low-grade glioma (LGG) in a child. The second case describes the MT in one of two tumors LGGs present in the same patient while the other tumor remained low grade. The first patient remains alive at the time of reporting the case while the second patient succumbed to his disease.