Testing the Asthma Predictive Index as a diagnostic tool in preschoolers: analysis of a longitudinal birth cohort
Jose A. Castro-Rodriguez,1 Erick Forno,2Oslando Padilla,3 Paola Casanello,1,4 Bernardo J. Krause5, Arturo Borzutzky1,6.
1Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.2Division of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, US. 3Department of Public Health, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.4Department of Obstetrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.5Instituto de Ciencias de la Salud, Universidad de O’Higgins, Rancagua, Chile. 6Millennium Institute on Immunology and Immunotherapy, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Corresponding author: Jose A. Castro Rodriguez, MD, PhD. Department of Pediatric Pulmonology, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile. Lira 44, 1er Piso, casilla 114-D, Santiago, Chile. Telephone: (56) 2 354 8189, FAX: (56) 2 354 8122, E-mail: jacastro17@homail.com
Author’s contributions: JACR conceptualized and designed the study; PC, BJK collaborated with the study design; OP performed all statistical analyses; EF, and AB supervised the analysis and revised the draft critically for important intellectual content. JACR wrote the first draft, and all authors read and approved the final manuscript.
Funding: Dr. Castro-Rodriguez’s contribution was funded by FONDECYT (# 1141195) from the Chilean Comisión Nacional Investigación Científica y Tecnológica (CONICYT). Dr. Forno´s contribution was supported by grant HL149693 from the U.S. NIH.
Clinical trial registry: This study is registered in ClinicalTrials.gov NCT02903134.
Financial Disclosure: The authors have no financial relationships relevant to this article to disclose.
Key words: asthma, diagnosis, preschoolers, recurrent wheezing, asthma predictive index.
Running head: API as an asthma diagnostic tool in preschoolers