Testing the Asthma Predictive Index as a diagnostic tool in
preschoolers: analysis of a longitudinal birth cohort
Jose A.
Castro-Rodriguez,1 Erick Forno,2Oslando Padilla,3 Paola
Casanello,1,4 Bernardo J. Krause5,
Arturo Borzutzky1,6.
1Division of Pediatrics, School of Medicine,
Pontificia Universidad Católica de Chile, Santiago, Chile.2Division of Pulmonary Medicine, Department of
Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh,
Pennsylvania, US. 3Department of Public Health, School
of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.4Department of Obstetrics, School of Medicine,
Pontificia Universidad Católica de Chile, Santiago, Chile.5Instituto de Ciencias de la Salud, Universidad de
O’Higgins, Rancagua, Chile. 6Millennium Institute on
Immunology and Immunotherapy, School of Medicine, Pontificia Universidad
Católica de Chile, Santiago, Chile.
Corresponding author: Jose A. Castro Rodriguez, MD, PhD.
Department of Pediatric Pulmonology, Division of Pediatrics, School of
Medicine, Pontificia Universidad Católica de Chile. Lira 44, 1er Piso,
casilla 114-D, Santiago, Chile. Telephone: (56) 2 354 8189, FAX: (56) 2
354 8122, E-mail: jacastro17@homail.com
Author’s contributions: JACR conceptualized and designed the
study; PC, BJK collaborated with the study design; OP performed all
statistical analyses; EF, and AB supervised the analysis and revised the
draft critically for important intellectual content. JACR wrote the
first draft, and all authors read and approved the final manuscript.
Funding: Dr. Castro-Rodriguez’s contribution was funded by
FONDECYT (# 1141195) from the Chilean Comisión Nacional Investigación
Científica y Tecnológica (CONICYT). Dr. Forno´s contribution was
supported by grant HL149693 from the U.S. NIH.
Clinical trial registry: This study is registered in
ClinicalTrials.gov NCT02903134.
Financial Disclosure: The authors have no financial
relationships relevant to this article to disclose.
Key words: asthma, diagnosis, preschoolers, recurrent wheezing,
asthma predictive index.
Running head: API as an asthma diagnostic tool in preschoolers