Clinical use in COVID-19
Nitazoxanide is an antiparasitic agent which also has antiviral
activities. Combined with hydroxychloroquine or azithromycin, a
synergistic effect has been suggested as hydroxychloroquine and
azithromycin inhibit viral entry and fusion, while nitazoxanide
upregulates innate immune response to prevent on-going viral replication
in COVID-19 (130).