Statistical analyses
Statistical analyses were performed using Statistical Package for the Social Sciences (IBM SPSS Statistics for Macintosh, Version 25.0) software. The continuous data were expressed as medians (interquartile range) due to their non-normal distribution, while the categorical variables were expressed as frequencies and percentages. For the group comparisons, the Mann–Whitney Utest and Pearson’sχ2test were used according to the data characteristics. The curves of freedom from adverse event were obtained using the Kaplan-Meier method and a log-rank test was used to compare the curves of the groups. In all statistical analyses, a P value ≤ 0.05 was considered to be statistically significant.