Figure 8: Citronellal or a minor constituent of citronella oil interferes with Orco. The ligand is either a negative allosteric modulator of Orco or an antagonist that is weakly competitive with VUAA1. The dilutions correspond to volumetric ratios of citronella oil and DMSO in an injection of 1 µL into the assay buffer.
3.7. Orco is not activated by oct-1-en-3-ol in human sweat