Author’s Contribution
HHS, EE and RLA conceived and designed the research study. LDC, MM, BP, MN, SB and RLA performed in vitro and in vivo experiments. Synthesis and chemical characterization of compounds was carried out by NNG and XB. NNG and RET conducted computational docking analysis. LDC, EE, HHS and RLA contributed to analysis and interpretation of data. HHS, EE, DP, JC and RLA were involved in revising the manuscript critically for important intellectual content. LDC and RLA wrote the manuscript.