Macrolides as Antivirals:
The novel antiviral mechanism of action of macrolides was discovered
when a significant improvement in the survival of patients with diffuse
pan-bronchiolitis (DPB) receiving low dose of Erythromycin was observed,
and when their beneficial effect was found to be independent of their
anti-microbial activity. Their administration was associated with
reduced inflammatory response in chronic airway diseases including upper
and lower respiratory tract infections (44) (45).