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OPTN:a promising target of autophagy to treat autophagy defective diseases
  • +3
  • Yueping Qiu,
  • Jiajia Wang,
  • Jincheng Wang,
  • Bo Yang,
  • Qiaojun He,
  • Qinjie Weng
Yueping Qiu
Zhejiang University - Zijingang Campus
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Jiajia Wang
Zhejiang University - Zijingang Campus
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Jincheng Wang
Zhejiang University - Zijingang Campus
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Bo Yang
Zhejiang University - Zijingang Campus
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Qiaojun He
Zhejiang University - Zijingang Campus
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Qinjie Weng
Zhejiang University - Zijingang Campus
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Abstract

Optineurin (OPTN) is a multifunctional adaptor protein that mainly involved in autophagy. While it was defined as an autophagy receptor and inducer, the extensive and important role in autophagy is hardly mentioned. What’s more, there are some critical disorders are closely related to OPTN, such as Glaucoma, Amyotrophic lateral sclerosis, Paget’s disease of bone, Crohn’s disease, cancer and diabetic nephropathy. This review will depict the OPTN involved autophagic process, from the recognition of cargo to the degradation in the autolysosome in molecular terms, and in particular highlight the process that compromised in disease related to OPTN. And we looking forward to strategies to modulate OPTN specifically with no toxic effects so that establish an efficient therapy for autophagy defective diseases.