Author Contributions:
Concept and design: Zehua wang, Jianfeng Guo, Jing Cai
Drafting of the manuscript: Jianfeng Guo, Jing Cai
Statistical analysis: Jianfeng Guo, Rui Gao
Date collection: Rui Gao, Man Xiao, Hui Ding, Wenjuan Qi
Conflict of Interest Disclosures: The authors report no
conflict of interest.
Funding/Support: This work was supported by the National
Natural Science Foundation of China [grant number 81672573].
Ethics approval: This study was approved by the Ethics
Committee of Wuhan Union Hospital, Tongji Medical College, Huazhong
University of Science and Technology [approval No.2020(0218)].
Acknowledgements: We wish to thank patients, and clinical staff
who provided significant contributions to this study.