loading page

Association between increase level of high-sensitive CRP (hs CRP) and non-arrhythmic ECG changes and echocardiographic abnormalities in patients with acute coronary syndrome
  • asghar rahmani,
  • roholla hemmati,
  • Seyed Hossein Kia
asghar rahmani
Author Profile
roholla hemmati
Author Profile
Seyed Hossein Kia
Author Profile

Abstract

Background: As elevation of serum C-reactive protein (CRP) is occurred following left ventricular dysfunction (LVD), relationship between increasing serum CRP level and abnormal changes in electrocardiography(ECG) pattern. The present study aimed to examine association between increase level of high-sensitive CRP (hs-CRP) and non-arrhythmic ECG changes and echocardiographic abnormalities in patients with acute coronary syndrome (ACS). Methods: This cross-sectional study was conducted on 120 consecutive patients finally diagnosed as ACS and hospitalized at cardiac care units (CCU). The participants were classified as the two groups with increased level or normal of hs-CRP level. Results: The patients with the increased level of hs-CRP had significantly higher level of cardiac enzymes. The group with increased level of hs-CRP experienced more ST-segment elevation myocardial infarction (STEMI) than those with normal serum hs-CRP level, but other diagnoses including unstable angina, non-STEMI, heart failure, and emergency hypertension were similarly observed in both groups. The two groups were comparable in terms of mean left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVeDD), prevalence of valvular heart diseases as well as in wall motion abnormality assessed by echocardiography. ST-segment elevation in different leads was more frequent in those with elevated hs-CRP level than in the group with normal hs-CRP condition (19.6% versus 1.4%, p = 0.001); but ST-segment depression and T wave inversion were similarly revealed in the two groups. Conclusion: Elevated level of hs-CRP can predict occurrence of STEMI, but may not be valuable to predict echocardiographic abnormalities including LVD or hypertrophy.