Supplementary File 2. Results of the single and combined reaction perturbations (gene knock-out simulations) on SARS-CoV-2 production, as performed on all reactions identified as flux-carrying in the flux variability analysis. Simulation results with the minimal media with two different uptake flux limits are shown (flux limits set to -10 or -1000 mmol∙gDW-1∙h-1). Effects of knock-outs are shown as percentage of optimal flux.