Supplementary File 5. Results of the single and combined reaction perturbations (gene knock-out simulations) on SARS-CoV-2 biomass and human lung cell specific maintenance pseudo reactions. Reaction pairs, whose combined perturbation results in a virus optimal biomass reduction below 80% of the original are shown. Simulation results with the minimal media with two different uptake flux limits are shown (flux limits set to -10 or -1000 mmol∙gDW-1∙h-1).