Association between OD and aetiology with relevant improvement in overall olfactory function
The next step included an analysis of associations between smell-loss related factors: (i) age, (ii) gender, (iii) aetiology of smell loss (infections, trauma, and idiopathic), (iv) duration of smell loss (months), (v) duration of training (weeks), (vi) baseline olfactory function, and (vii) presence of parosmia or phantosmia at initial visit with clinically relevant recovery of overall olfactory function (defined as TDI improvement greater or equal 5.5 points) at follow-up visit. Therefore, a binary logistic regression model was computed.
Analysis revealed that relevant recovery of overall olfactory performance was more likely in those that had lower baseline olfactory function (adjusted odds ratio; aOR, 0.93; 95%CI, 0.88-0.97;Table 2 ), and postinfectious OD compared to posttraumatic (aOR, 0.28; 95%CI, 0.10-0.81) or idiopathic OD (aOR, 0.16; 95%CI, 0.06-0.41).