Patients
An existing HSCT program database was used to identify all pediatric/AYA
patients who underwent first HSCT at a single academic children’s
hospital from 2007-2016. Demographic and clinical data were extracted
from this database and electronic health records through March 31, 2017
via research informatics and manual review. Inclusion criteria were: 1)
age 0-30 at time of transplant, and 2) allogeneic or autologous HSCT
recipient at Children’s Hospital Colorado between January 1, 2007 and
July 31, 2016. Exclusion criteria were: 1) pre-existing diabetes
mellitus, 2) insulin requirement within the two weeks prior to
transplant, and 3) inadequate blood glucose data (<20
measurements total or <2 in a given period (pre-HSCT and
post-HSCT day 0-30)). Of 351 patients identified, the primary analyses
included 344 patients. Four additional patients were excluded only from
pre-HSCT analyses due to too few glucose measurements pre-HSCT (n=340
for these analyses). This study was approved by the University of
Colorado Institutional Review Board.