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Infant T-Cell Acute Lymphoblastic Leukemia Presenting with Macrocephaly: A Case Report
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  • Victoria Brocksmith,
  • Sudarshawn Damodharan,
  • Mallery Olsen,
  • Susan Rebsamen,
  • Margo Hoover-Regan
Victoria Brocksmith
University of Wisconsin Madison
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Sudarshawn Damodharan
University of Wisconsin Madison
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Mallery Olsen
University of Wisconsin Madison School of Medicine and Public Health
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Susan Rebsamen
University of Wisconsin Madison School of Medicine and Public Health
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Margo Hoover-Regan
University of Wisconsin Madison School of Medicine and Public Health
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Abstract

A 6.5-month-old girl presented to a pediatrician for a second opinion regarding worsening macrocephaly and developmental regression. She then underwent neurosurgical evaluation. Rapid-sequence magnetic resonance imaging was significant for benign enlargement of the subarachnoid space of infancy. A complete blood count was significant for 33% blasts in the peripheral blood. Flow cytometry of the peripheral blood established a diagnosis of T-cell Acute Lymphoblastic Leukemia (ALL). T-cell ALL has been rarely reported and our patient’s presentation with macrocephaly is particularly unique.