Figure 3. Activity of TeNT and TeNT + Decoy molecules in naïve
mice. A) Time course of tetany stage induced by 0.01 ng of TeNT (Blue)
compared to 0.01 ng TeNT with 100 µg of equimolar decoy solution (Red).B) Time course of tetany stage induced by 0.1 ng of TeNT (Blue)
and 0.1 ng TeNT with 100 µg of equimolar decoy solution (Red).C) Time course of tetany stage induced by 1 ng of TeNT (Blue)
and 1 ng TeNT with 100 µg of equimolar decoy solution (Red). Multiple
t-test analyses were performed and statistical significance determined
using the Holm-Sidak method, with alpha = 0.05. Each time point was
analysed individually, without assuming a consistent SD. An asterisk
denotes a time point with statistical significance (p < 0.05).
The error bars show the range of tetany stages observed at each time
point and where no error bar is displayed, all animals displayed the
same stage of tetanus.