Conclusion and Implications:
Our results clearly demonstrate that the barriers to developing a
tetanus toxin therapeutic are not insurmountable and the technology
presented here is the first major step towards realising the therapeutic
potential of this powerful neurotoxin. Opening the therapeutic potential
of tetanus toxin will have huge implication for the wide range of
diseases caused by low-tone muscle.
Keywords: Tetanus toxin, muscle tone, sleep apnoea, protein
therapeutic, immune evasion, immunological smokescreen, skeletal muscle