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Prognostic value of CD4+T cell in patients with severe COVID-19
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  • xuesong wen,
  • Lei Gao,
  • dan jiang,
  • xiaocheng cheng,
  • bin he,
  • yue chen,
  • peng lei,
  • xiaowei tan,
  • shu qin,
  • guoqiang cai,
  • dongying zhang
xuesong wen
Chongqing Medical University First Affiliated Hospital
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Lei Gao
Chongqing Medical University First Affiliated Hospital
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dan jiang
The First Branch of the First Affiliated Hospital of Chongqing Medical University
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xiaocheng cheng
Chongqing Medical University First Affiliated Hospital
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bin he
Chongqing Medical University First Affiliated Hospital
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yue chen
Chongqing Medical University First Affiliated Hospital
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peng lei
Chongqing Medical University First Affiliated Hospital
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xiaowei tan
Chongqing Medical University First Affiliated Hospital
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shu qin
Chongqing Medical University First Affiliated Hospital
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guoqiang cai
Traditional Chinese Medicine hospital Dianjiang Chongqing
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dongying zhang
Chongqing Medical University First Affiliated Hospital
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Abstract

Abstract Background In December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, Hubei, China. Finding markers that predict the prognosis of patients with severe COVID-19 are of great value. Methods In this single-center´╝îretrospective study, 157 patients with severe COVID-19 were recruited from a consecutive series. After screening, a total of 105 patients were included in this study. All-cause death was the primary endpoint. All patients were followed up from admission till discharge or death. Results The dominant symptoms observed in the study included fever on admission, cough, fatigue and shortness of breath. The most frequent comorbidities were hypertension and diabetes. Compared with patients with higher CD4+T cells level, patients with lower CD4+T cells level were older and were more frequently male. In terms of laboratory findings, lymphocyte percentage, lymphocyte absolute value, CD3+T cell count, CD4+T cell count, CD8+T cell count were significantly lower in low group than in high group. The case in-hospital death rate was significant higher in patients with lower CD4+T level than in those with higher CD4+T level. After adjusting for potential confounding factors, CD4+T cells count below normal values showed independent prognostic value for all-cause in-hospital death in patients with severe COVID-19. Conclusions In patients with severe COVID-19, lower CD4+T cells count are independently associated with an increased rate of in-hospital death.