Conclusions:
Children aged less than five years with DKA have a higher risk of developing CVC-associated VTE than similarly aged children with CVC placement for any other reason. In our population, no demographic or laboratory markers were found to effectively predict which children with DKA would develop CVC-associated VTE. In accordance with published guidelines, CVC use in the management of pediatric DKA should be avoided if possible, but, if a CVC is placed, prophylaxis with standard or low molecular weight heparin should be strongly considered for all patients and the duration of CVC use should be limited by medical necessity.